Points to be addressed: Hyperglycemia- induced neuronal mitochondrialdysfunction and insulin resistance: Peripheral lipid/glucose metabolic remodeling inAPP/PS1 mouse Potential Biomarkers for early diagnosis of ADTarget mitochondria by mitochondrial nutrients:Hydroxytyrosol and Hydrogen
Points to be addressed • Hyperglycemia- induced neuronal mitochondrial dysfunction and insulin resistance • Peripheral lipid/glucose metabolic remodeling in APP/PS1 mouse • Potential Biomarkers for early diagnosis of AD • Target mitochondria by mitochondrial nutrients: Hydroxytyrosol and Hydrogen
Lipid MetabolisminADHigher body weight gain, exacerbated hyperglycemiaand glucose intolerance in AD mice subjected to HFDABChowWT60150口WTChowADww)AD★HFDWT(0) iopmDiet:p<0.0001HFDADAPOBGenotype: p<0.01Time:p<0.0001Genotype: p<0.0001Interaction:p<0.01Diet:p<0.0001nrenTime'Genotype: p<0.000150Time'Diet:p<0.0001Genotype'Diet:p<0.000Time'Genotype'Diet: p<0.0001141618202224262830323436(Week)1416182022242628303436(Week)ChowHFDcDOGTTChow+InsHFD+InsChow WT2520WTADWTADWTChowADAD+HFDWT20p-Akt(S473)(,4wulDiet p<0.0001HFD ADGenotype: p<0.000115Interaction:p>0.05p-Akt(T308)ne10AktActin601530120 (min)ChowHFDnYingTang,etal.JournalofNeurochemistry,2016
Lipid Metabolism in AD Higher body weight gain, exacerbated hyperglycemia and glucose intolerance in AD mice subjected to HFD Ying Tang, et al. Journal of Neurochemistry, 2016