Mitochondrial Biology and medicineMt structure and functionJiangangLong,PHDInstituteofMitochondrialBiology andMedicineSchoolofLifeScienceandTechnology,XJTU
Mitochondrial Biology and medicine －Mt structure and function Jiangang Long，PHD Institute of Mitochondrial Biology and Medicine School of Life Science and Technology, XJTU
Mitochondrial Structureand functionDiscoveryofmitochondria1.Intracellularsitellocationlvolume2.Mtstructure3.Mt structure1Mt originII.Mt DNAII.Mt function4.Metabolisminmitochondria1.Electrontransportationchain(ETC)2.beta oxidation3
Mitochondrial Structure and function 1. Discovery of mitochondria 2. Intracellular site\location\volume 3. Mt structure I. Mt structure II. Mt origin III. Mt DNA 4. Mt function 1. Metabolism in mitochondria 2. Electron transportation chain (ETC) 3. beta oxidation 2
In1894.mitochondriawerefirstdiscoveredMitochondrionGolgicomplexPeroxisomeNudeusPlasmamembraneEndoplasmicreticulum3Ribosomes
3 In 1894, mitochondria were first discovered
In1894.mitochondriawerefirstdiscoveredIn1897,officiallynamedas"Mitochondria
4 In 1897, officially named as “Mitochondria”. In 1894, mitochondria were first discovered
1894年，首次发现线粒体In1894,mitochondriawerefirstdiscovered1897，正式命名为mitochondria（线粒体）In 1897, officially named as“"Mitochondria".1963年，Nass车鸡旺中++友车DNAIn1963,Nassfouembryos.SchaONASchat1981年，测定mined.In1981.DNAsec1987年，Wallace捉出mtvNA尖可引起疾病In 1987, Wallace proposes that mtDNAmutations may causedisease1988年，首次报道mtDNA突变In1988,mtDNAmutationswerefirstreported.5
5 1963年，Nass在鸡胚中发现线粒体中存在DNA Schatz分离到完整的线粒体DNA 1981年，测定人mtDNA的DNA序列 1987年，Wallace提出mtDNA突变可引起疾病 1988年，首次报道mtDNA突变 1897，正式命名为mitochondria (线粒体) In 1897, officially named as “Mitochondria”. 1894年，首次发现线粒体 In 1894, mitochondria were first discovered. In 1963, Nass found DNA in mitochondria in chicken embryos. Schatz isolated the entire mitochondrial DNA In 1981, DNA sequence of human mtDNA was determined. In 1987, Wallace proposes that mtDNA mutations may cause disease. In 1988, mtDNA mutations were first reported