《多尺度生物传输》课程教学大纲 Multi-scale Biotransport

西安交通大学研究生课程简介课程编码：BIOL711313课程名称：（中）多尺度生物传输课程名称：（英）Multi-scaleBiotransport学分数：2课内总学时数：40实验学时数：8（计算机模拟）课程内容简介：随着激光、微波及相关技术的发展，各种针对皮肤疾病和损伤（皮肤癌、烧伤、纹身去除等）、牙科疾病（龋齿预防与治疗、牙本质过敏治疗）以及肿瘤的新的热疗方法不断涌现。热疗（温度）方法的目的是引入热效应使生物组织发生一系列的物理、化学变化，从而达到治疗的目的，然而热疗过程中产生的热损伤和热疼痛等问题严重影响临床医学治疗效果。最理想的治疗方案应具有效果佳而副作用最小的特点，但由于热疗疗效受生物组织的传热学、力学、生物学和神经反应等多方面复杂因素所决定，阻碍了临床热疗方法的发展。因此，针对与热疗密切相关的多尺度生物传输与神经生理学问题，课程教学将围绕以下主要内容展开：1）多尺度生物传输概念；2）两种典型人体软组织（皮肤）和硬组织（牙齿）的解剖结构及相应的神经分布特点；3）生物组织热-力耦合及神经

西安交通大学研究生课程简介 课程编码： BIOL711313 课程名称：（中）多尺度生物传输 课程名称：（英）Multi-scale Biotransport 学分数： 2 课内总学时数：40 实验学时数： 8 （计算机模拟） 课程内容简介：随着激光、微波及相关技术的发展，各 种针对皮肤疾病和损伤（皮肤癌、烧伤、纹身去除等）、 牙科疾病（龋齿预防与治疗、牙本质过敏治疗）以及肿瘤 的新的热疗方法不断涌现。热疗（温度）方法的目的是引 入热效应使生物组织发生一系列的物理、化学变化，从而 达到治疗的目的，然而热疗过程中产生的热损伤和热疼痛 等问题严重影响临床医学治疗效果。最理想的治疗方案应 具有效果佳而副作用最小的特点，但由于热疗疗效受生物 组织的传热学、力学、生物学和神经反应等多方面复杂因 素所决定，阻碍了临床热疗方法的发展。因此，针对与热 疗密切相关的多尺度生物传输与神经生理学问题，课程教 学将围绕以下主要内容展开：1）多尺度生物传输概念；2） 两种典型人体软组织（皮肤）和硬组织（牙齿）的解剖结 构及相应的神经分布特点；3）生物组织热-力耦合及神经

生理学实验基础：4）冷热剩激下人体组织热一力耦合、热损伤本构关系；5）Hodgkin-Huxley电神经生理学模型及理论基础：6）冷热刺激引发疼痛信号及大脑对疼痛信号的感知等的统一模型理论基础；7）多尺度生物传输与神经生理学研究应用实例。从事相关生物物理或生物数学研究的研究生将从课程中学习到多尺度生物传输相关的数理建模及验证性实验设计的基础知识。医学相关专业的研究生将掌握采用数理模型对临床热治疗方法进行预测与优化临床诊疗方法，为临床实践提供参考。先修课：数值分析参考书目：1.F.Xu TJ.Lu,“Introduction to Skin Biothermomechanics and Thermal Pain", SpringerChina, 2010Xu, F, 2008, "Skin biothermomechanics and thermal pain," PhD Thesis,2.University ofCambridge, Cambridge,UK.林敏，牙组织传热及冷/热疼痛机制的生物热-力耦合学研究.博士学位论文，3.西安交通大学4.姜宗来、樊瑜波编著《生物力学一一从基础到前沿》，科学出版社，20075. Xu, F., Lu, T J., and Seffen, K. A., Skin thermal pain modeling. a holisticmethod," Journal of Thermal Biology,2008,33(4):223-237.6.Xu, F., Seffen, K.A.,and Lu, T J., Non-Fourier analysis of skinbiothermomechanics.International Journal ofHeatand Mass Transfer,200851:2237-2259.7.Xu, F., Wen, T., Lu, T. J., and Seffen, K. A., Modelling of nociceptor transductionin skinthermal pain sensation.Journal of Biomechanical Engineering,2008130(4):1-13.8. Xu, F., Wen, T., Seffen, K. A., and Lu, T J., Biothermomechanics of skin tissueJournaloftheMechanicsandPhysicsofSolids,2008,56(5):1852-1884Xu, F., Lu, T. J., and Seffen, K. A., Thermally-induced change in the relaxation9.behaviour of skin tissue. ASME Journal of Biomechanical Engineering.2008

生理学实验基础；4）冷热刺激下人体组织热-力耦合、热 损伤本构关系；5）Hodgkin-Huxley 电神经生理学模型及 理论基础；6）冷热刺激引发疼痛信号及大脑对疼痛信号 的感知等的统一模型理论基础；7）多尺度生物传输与神 经生理学研究应用实例。从事相关生物物理或生物数学研 究的研究生将从课程中学习到多尺度生物传输相关的数 理建模及验证性实验设计的基础知识。医学相关专业的研 究生将掌握采用数理模型对临床热治疗方法进行预测与 优化临床诊疗方法，为临床实践提供参考。 先修课: 数值分析 参考书目： 1． F. Xu, T.J. Lu, “Introduction to Skin Biothermomechanics and Thermal Pain”, Springer, China, 2010 2． Xu, F., 2008, "Skin biothermomechanics and thermal pain," PhD Thesis, University of Cambridge, Cambridge, UK. 3． 林敏，牙组织传热及冷/热疼痛机制的生物热-力耦合学研究. 博士学位论文， 西安交通大学 4． 姜宗来、樊瑜波编著《生物力学——从基础到前沿》，科学出版社，2007 5． Xu, F., Lu, T. J., and Seffen, K. A., Skin thermal pain modeling. a holistic method," Journal of Thermal Biology, 2008, 33(4):223-237. 6． Xu, F., Seffen, K. A., and Lu, T. J., Non-Fourier analysis of skin biothermomechanics. International Journal of Heat and Mass Transfer, 2008, 51:2237-2259. 7． Xu, F., Wen, T., Lu, T. J., and Seffen, K. A., Modelling of nociceptor transduction in skin thermal pain sensation. Journal of Biomechanical Engineering, 2008, 130(4):1-13. 8． Xu, F., Wen, T., Seffen, K. A., and Lu, T. J., Biothermomechanics of skin tissue. Journal of the Mechanics and Physics of Solids, 2008, 56(5):1852-1884. 9． Xu, F., Lu, T. J., and Seffen, K. A., Thermally-induced change in the relaxation behaviour of skin tissue. ASME Journal of Biomechanical Engineering. 2008

130 (4), 1-131o. Xu, F., Lu, T. J., Seffen, K. A., and Ng, E. Y. K., Bioheat transfer of skin tissueApplied Mechanics Review,2009, 62(5), 05080111. Lin, M, Luo, Z.Y., Bai, B.F., Xu,F., Lu,TJ. Fluid mechanics in dentinal microtubulesprovides mechanistic insights into the difference between hot and cold dental pain, PLosONE,2011, 6(3):e18068.12.Lin, M., Liu, S.B., Niu, L., Feng,X., Lu,T.J.Analysis of thermal-induced dentinal fluid flowand its implications in dental thermal pain.ArchivesofOral Biology,201l,56(9)846-85613. Lin, M, Luo, Z.Y., Bai, B.F, Xu,F., Lu,T.J.Fluid dynamics analysis of shear stress on nerveendings in dentinal microtubule:Aquantitative interpretation of hydrodynamic theoryfortooth pain. Journal of Mechanics in Medicine and Biology, 2011,11(1):205-219.14.Lin, M.,Zai,X.,S.Q.Wang.Wang,ZJ., Xu,F., Lu, TJ.Influences of Supra-physiologicalTemperatures on Microstructure and Mechanical Properties of Skin Tissue. MedicalEngineering& Physics, 2011, DO1:10.1016/j.medengphy.2011.12.00315.Lin,M.,Xu.F.Lu,TJ.,Bai,B.F.Areviewof heattransferinhumantooth-Experimentalcharacterization and mathematical modeling.Dental Materials, 2010,26(6):501-51316．徐峰，林敏，卢天健，Seffen,K.A，Ng,E.Y.K皮肤生物热传导模型综述。中国力学文摘,2010,24(2):1-3817.林敏,刘少宝，牛林，徐峰卢天健，牙齿热疼痛流体动力学假说的证实与完善，西安交通大学学报,2011,45(12):118-122.执笔人：徐峰、林敏审定人：张建保

130 (4), 1-13 10．Xu, F., Lu, T. J., Seffen, K. A., and Ng, E. Y. K., Bioheat transfer of skin tissue. Applied Mechanics Review, 2009, 62(5), 050801 11．Lin, M., Luo, Z.Y., Bai, B.F., Xu,F., Lu,T.J. Fluid mechanics in dentinal microtubules provides mechanistic insights into the difference between hot and cold dental pain. PLoS ONE, 2011, 6(3): e18068. 12．Lin, M., Liu, S.B., Niu, L., Feng, X., Lu,T.J. Analysis of thermal-induced dentinal fluid flow and its implications in dental thermal pain. Archives of Oral Biology, 2011, 56(9) 846-856. 13．Lin, M., Luo, Z.Y., Bai, B.F., Xu,F., Lu,T.J. Fluid dynamics analysis of shear stress on nerve endings in dentinal microtubule: A quantitative interpretation of hydrodynamic theory for tooth pain. Journal of Mechanics in Medicine and Biology, 2011,11(1):205–219. 14．Lin, M., Zai, X., S.Q. Wang, Wang, Z.J., Xu, F., Lu, T.J. Influences of Supra-physiological Temperatures on Microstructure and Mechanical Properties of Skin Tissue. Medical Engineering & Physics, 2011, DOI:10.1016/j.medengphy.2011.12.003 15．Lin, M., Xu,F., Lu,T.J., Bai, B.F. A review of heat transfer in human tooth—Experimental characterization and mathematical modeling. Dental Materials, 2010,26(6):501-513. 16．徐峰，林敏，卢天健，Seffen, K.A., Ng, E.Y.K. 皮肤生物热传导模型综述. 中国力学文 摘, 2010,24(2):1-38. 17．林敏,刘少宝,牛林,徐峰,卢天健. 牙齿热疼痛流体动力学假说的证实与完善，西安交通大 学学报,2011,45(12):118-122. 执笔人：徐峰、林敏 审定人： 张建保

Course Code:Course Name:Multi-scale BiotransportCredit:2Teaching Hours:40ExperimentalHours:8Introduction:Advances in laser, microwave and similar technologies in medicine have ledto recent developments of thermal treatments for disease and injury, involving skinand tooth tissues. In spite of the widespread use of thermal therapies, they do not drawupon the detailed understanding of the biotransport processes at multi-scale (e.g.,biothermomechanical-neurophysiological behavior), for none exists to date, eventhough each behavioral facet is somewhat established and understood. In view of thisdilemma,a newresearch area emerges,whichisthesubject of thiscourse“Multi-scale Biotransport.This area is highly interdisciplinary, involving thesubjects of engineering, biology and neurophysiology. This course is focused on theintroduction of this new research area.According to the schematic relationshipbetweentheareasinvolved,thiscourseismainlydivided intoSevenPartsPARTI.Introductionofmulti-scalebiotransportPARTII. Microstructure and nerve innervations of skin and tooth tissues;PART IIl. Experimental basis of tissue bioheat transfer and resultingthermomechanics and thermal damage,PARTIV.Theoretical and numerical approaches for tissue bioheat transfer andresulting biothermomechanics and thermal damage

Course Code: Course Name: Multi-scale Biotransport Credit: 2 Teaching Hours： 40 Experimental Hours: 8 Introduction: Advances in laser, microwave and similar technologies in medicine have led to recent developments of thermal treatments for disease and injury, involving skin and tooth tissues. In spite of the widespread use of thermal therapies, they do not draw upon the detailed understanding of the biotransport processes at multi-scale (e.g., biothermomechanical-neurophysiological behavior), for none exists to date, even though each behavioral facet is somewhat established and understood. In view of this dilemma, a new research area emerges, which is the subject of this course: ‘Multi-scale Biotransport’. This area is highly interdisciplinary, involving the subjects of engineering, biology and neurophysiology. This course is focused on the introduction of this new research area. According to the schematic relationship between the areas involved, this course is mainly divided into Seven Parts: PART I. Introduction of multi-scale biotransport PART II. Microstructure and nerve innervations of skin and tooth tissues; PART III. Experimental basis of tissue bioheat transfer and resulting thermomechanics and thermal damage; PART IV. Theoretical and numerical approaches for tissue bioheat transfer and resulting biothermomechanics and thermal damage;

PART V. Introduction of Hodgkin-Huxley model;PARTVI.Holistic model fortissue thermal pain sensations;PARTVII.Examples and applications of multi-scale biotransportThe course is multidisciplinary suitable for students across several subjectareas. These areas involve biophysics, biomathematics, biomedical engineering aswell as clinics.Required Course in Advance: numerical analysisReferences:1.F.Xu, TJ.Lu,“Introduction to Skin Biothermomechanics and Thermal Pain, Springer,China, 20102.Xu,F.,2008, "Skin biothermomechanics and thermal pain,"PhD Thesis,University ofCambridge,Cambridge,UK3.林敏，牙组织传热及冷/热疼痛机制的生物热-力耦合学研究.博士学位论文，西安交通大学姜宗来、樊瑜波编著《生物力学一一从基础到前沿》，科学出版社，20074.5.Xu, F., Lu, T. J., and Seffen, K. A., Skin thermal pain modeling. a holisticmethod," Journal of Thermal Biology, 2008, 33(4):223-237.Xu, F., Seffen, K. A., and Lu, T. J., Non-Fourier analysis of skin6.biothermomechanics. International Journal of Heat and Mass Transfer, 2008,51:2237-2259Xu, F., Wen, T., Lu, T. J., and Seffen, K. A., Modelling of nociceptor transduction7.in skin thermal pain sensation.Journal of Biomechanical Engineering,2008130(4):1-13.8. Xu, F., Wen, T., Seffen, K. A., and Lu, T. J., Biothermomechanics of skin tissue.Journal of the Mechanics and Physics of Solids, 2008, 56(5):1852-1884.Xu, F., Lu, T. J., and Seffen, K. A., Thermally-induced change in the relaxation9.behaviour of skin tissue. ASME Journal of Biomechanical Engineering. 2008130 (4), 1-131o. Xu, F., Lu, T. J., Seffen, K. A., and Ng, E. Y. K., Bioheat transfer of skin tissue.AppliedMechanicsReview,2009,62(5),0508011l. Lin, M, Luo, Z.Y, Bai, B.F., Xu,F., Lu,TJ. Fluid mechanics in dentinal microtubulesprovides mechanistic insights into the difference between hot and cold dental pain. PLoS

PART V. Introduction of Hodgkin-Huxley model; PART VI. Holistic model for tissue thermal pain sensations; PART VII. Examples and applications of multi-scale biotransport The course is multidisciplinary suitable for students across several subject areas. These areas involve biophysics, biomathematics, biomedical engineering as well as clinics. Required Course in Advance: numerical analysis References: 1． F. Xu, T.J. Lu, “Introduction to Skin Biothermomechanics and Thermal Pain”, Springer, China, 2010 2． Xu, F., 2008, "Skin biothermomechanics and thermal pain," PhD Thesis, University of Cambridge, Cambridge, UK. 3． 林敏，牙组织传热及冷/热疼痛机制的生物热-力耦合学研究. 博士学位论文， 西安交通大学 4． 姜宗来、樊瑜波编著《生物力学——从基础到前沿》，科学出版社，2007 5． Xu, F., Lu, T. J., and Seffen, K. A., Skin thermal pain modeling. a holistic method," Journal of Thermal Biology, 2008, 33(4):223-237. 6． Xu, F., Seffen, K. A., and Lu, T. J., Non-Fourier analysis of skin biothermomechanics. International Journal of Heat and Mass Transfer, 2008, 51:2237-2259. 7． Xu, F., Wen, T., Lu, T. J., and Seffen, K. A., Modelling of nociceptor transduction in skin thermal pain sensation. Journal of Biomechanical Engineering, 2008, 130(4):1-13. 8． Xu, F., Wen, T., Seffen, K. A., and Lu, T. J., Biothermomechanics of skin tissue. Journal of the Mechanics and Physics of Solids, 2008, 56(5):1852-1884. 9． Xu, F., Lu, T. J., and Seffen, K. A., Thermally-induced change in the relaxation behaviour of skin tissue. ASME Journal of Biomechanical Engineering. 2008, 130 (4), 1-13 10．Xu, F., Lu, T. J., Seffen, K. A., and Ng, E. Y. K., Bioheat transfer of skin tissue. Applied Mechanics Review, 2009, 62(5), 050801 11．Lin, M., Luo, Z.Y., Bai, B.F., Xu,F., Lu,T.J. Fluid mechanics in dentinal microtubules provides mechanistic insights into the difference between hot and cold dental pain. PLoS