AUDTE21-学与技Mitochondrial Metabolic Disorder in Alzheimer's Disease:Targeting Mitochondria for Diagnosis and PreventionJiangang Longjglong@mail.xjtu.edu.cnInstitute of Mitochondrial Biology and MedicineIMBMXi'an Jiaotong University, Xi'an
Mitochondrial Metabolic Disorder in Alzheimer’s Disease: Targeting Mitochondria for Diagnosis and Prevention Jiangang Long jglong@mail.xjtu.edu.cn Institute of Mitochondrial Biology and Medicine, IMBM Xi’an Jiaotong University, Xi’an
糖尿病在中国迅速发展Diabetes in China 2010113.9 million Chinese adults with diabetes (11.6%)493.4 million with prediabetes (50.1%)ADiabetesBPrediabetes30.080.025.0MenWomerde060.020.015.040.010.020.05.00.00.018-2950-5960-69≥7030-3940-4918-2930-3940-4950-5960-69≥70Age, yAge,yJAMA.2013:310(9):948-958
糖尿病在中国迅速发展 Diabetes in China 2010 • 113.9 million Chinese adults with diabetes (11.6%) • 493.4 million with prediabetes (50.1%) JAMA. 2013;310(9):948-958
China: An Aging Society19502010China's60+PopulationMalesFemales2010-2050437M248M20502100167MSooreerCehetXutioesPogulatioeDividionMTT.ALa,200D2010202020504(millions)Age and gender structure of China,1950,2010,2050, and2100.Source: UNDESA(2011)3
China: An Aging Society 3
AD: a systemic metabolic disease·AD affects boththeCNS andperipheryBaselineRisk·ADtransgenicmiceMitochondrial Genes(COX,etc)NuclearGenes·develop liver insulinAPOE4,TOMM40,etc)InsulinResistance (+)resistanceExercise (-)Potential risk·increased susceptibilitytoAdvancingage (+)modifiersHeart healthydiet-induced obesity anddiet (-)Vascularevents (+)Education (-)glucose intoleranceMidlife obesity (+).Liverand skeletalmuscleOther/Unknowinsulin resistanceindiabeticob/ob micewasexacerbatedbyCumulativelate-onsetADriskcrossbreedingwithAPP23miceBiochimBiophysActa.2014
AD: a systemic metabolic disease • AD affects both the CNS and periphery • AD transgenic mice • develop liver insulin resistance • increased susceptibility to diet-induced obesity and glucose intolerance • Liver and skeletal muscle insulin resistance in diabetic ob/ob mice was exacerbated by crossbreeding with APP23 mice Biochim Biophys Acta. 2014
糖尿病与老年痴呆病存在关联Cognitive function and diabetesCognitivefunctionwasimpaired in diabeticsubjects.(Archives ofphysical medicine andpancreaticncretininsulineffectrehabilitation.2013)secretionpancreaticucagon？secretionPUDiabetes is amajorriskfactorforcarbohydratedelivery&HYPERGLYCEMIAabsorptionneurodegenerative diseases suchas AD.(Neurology.2011)peripheralhepaticglucoseglucoseuptakeHyperinsulinemia and hyperlipidemia arisingnroductianfromdiabeteshavebeenlinkedtoneuronalinsulinresistanceEndocrinology,2011;Neuropharmacology,2009)
糖尿病与老年痴呆病存在关联 Cognitive function and diabetes • Cognitive function was impaired in diabetic subjects. (Archives of physical medicine and rehabilitation. 2013 ) • Diabetes is a major risk factor for neurodegenerative diseases such as AD. (Neurology. 2011) • Hyperinsulinemia and hyperlipidemia arising from diabetes have been linked to neuronal insulin resistance Endocrinology,2011; Neuropharmacology,2009)