Mitochondrial biology and medicine-mitochondrialgenetics龙建纲JiangangLongInstituteof MitochondrialBiologyand MedicineSchoolofLifeScienceandTechnology,XJTU
1 Mitochondrial biology and medicine -mitochondrial genetics 龙 建 纲 Jiangang Long Institute of Mitochondrial Biology and Medicine School of Life Science and Technology, XJTU
The Nobel Prize in Physiology or Medicine 2021David Julius and Ardem Patapoutian"fortheir discoveriesof receptors fortemperature and touch
David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch”. The Nobel Prize in Physiology or Medicine 2021
The Nobel Prizein Physiologyor Medicine2021PIEZ01TRPV1PIEZ02TouchTemperatureHeatpainProprioception
The Nobel Prize in Physiology or Medicine 2021
Discoveries of receptors fortemperatureand touch60TemperatureHeatpainTRPV1Closed50TRPM3TRPA1SensoryneuronTRPV140RNATRPM2+30DNAfragments20>43℃OpenTRPM8CapsaicinOCH100lonsCFigure2DavidJuliususedcapsaicinfromchilipepperstoidentifyTRPV1,anionchannelactivatedbypainfulheat.Additionalrelatedionchannelswereidentifiedandwenowunderstandhowdifferenttemperaturescaninduceelectricalsignalsinthenervous system
Discoveries of receptors for temperature and touch Figure 2 David Julius used capsaicin from chili peppers to identify TRPV1, an ion channel activated by painful heat. Additional related ion channels were identified and we now understand how different temperatures can induce electrical signals in the nervous system
DiscoveriesofreceptorsfortemperatureandtouchGene silencingGene silencingMeasureMechanical forceMechanical forceMeasurCellCellCandidate gene 1-71Candidate gene 72TouchPIEZ01ProprioceptionClosedPIEZ02Mechanical forceOpenlonsFigure3Patapoutianusedculturedmechanosensitivecellstoidentifyanionchannelactivatedbymechanicalforce.Afterpainstakingwork,Piezo1wasidentified.BasedonitssimilaritytoPiezo1,asecondionchannelwasfound(Piezo2)
Figure 3 Patapoutian used cultured mechanosensitive cells to identify an ion channel activated by mechanical force. After painstaking work, Piezo1 was identified. Based on its similarity to Piezo1, a second ion channel was found (Piezo2). Discoveries of receptors for temperature and touch