二 授课内容（依据教学大纲）及时间分配 Get a general idea about adrenaline and its functions and neurochemistry 15 min Get a general idea about the distribution,structures and functions of norepinephrine receptor 5min Get a general idea about drugs affecting adrenergic neurotransmission 5min To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major drugs affecting adrenergic neurotransmission;Understand the synthesis and metabolism of major drugs affecting adrenergic neurotransmission Including the following specific drugs(75 min): Alpha1 Adrenergic Agonists:Phenylethanolamines;2- Arylimidazolines 5min Alpha2 Adrenergic Agonists:2-Aminoimidazolines(e.g.Clonidine) 10 min Beta1 Adrenergic Agonists:Dobutamine 10 min Beta2 Adrenergic Agonists:Phenylethanolamines (e.g.Isoproterenol; albuterol,salmeterol) 20 min Alpha1 Adrenergic Antagonists:Prazosin 10 min Beta Adrenergic Antagonists:aryloxypropanolamines (e.g. Propranolol;Metoprolol) 20 min
二、 授课内容（依据教学大纲）及时间分配 Get a general idea about adrenaline and its functions and neurochemistry 15 min Get a general idea about the distribution, structures and functions of norepinephrine receptor 5 min Get a general idea about drugs affecting adrenergic neurotransmission 5 min To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major drugs affecting adrenergic neurotransmission; Understand the synthesis and metabolism of major drugs affecting adrenergic neurotransmission Including the following specific drugs (75 min): Alpha1 Adrenergic Agonists: Phenylethanolamines; 2- Arylimidazolines 5 min Alpha2 Adrenergic Agonists: 2-Aminoimidazolines (e.g. Clonidine) 10 min Beta1 Adrenergic Agonists: Dobutamine 10 min Beta2 Adrenergic Agonists: Phenylethanolamines (e.g. Isoproterenol; albuterol, salmeterol) 20 min Alpha1 Adrenergic Antagonists: Prazosin 10 min Beta Adrenergic Antagonists: aryloxypropanolamines (e.g. Propranolol; Metoprolol) 20 min
三、 教学重点与难点 1.教学重点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major adrenergic drugs 2.教学难点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major adrenergic drugs 四、 教学方法选择 5.理论课堂教学 A.多媒体教学： (简要列出本章节多媒体教学设计特点及优势) B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题)】 6.实验教学： (简要列出实验内容标题)
三、 教学重点与难点 1. 教学重点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major adrenergic drugs 2. 教学难点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major adrenergic drugs 四、 教学方法选择 5. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题） 6. 实验教学：（简要列出实验内容标题）
五、 更新或补充内容提要 六、 复习思考题 Please explain why salmeterol,Indacaterol and Formoterol are long-lasting B2 adrenergic agonists compared to Albuterol?And why Indacaterol have the longest duration of time? 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期肝刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
五、 更新或补充内容提要 六、 复习思考题 Please explain why salmeterol, Indacaterol and Formoterol are long-lasting β2 adrenergic agonists compared to Albuterol? And why Indacaterol have the longest duration of time? 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
苏州大学医学部药学院授课教案 授课教师：叶娜 授课日期：2020.9.29 课程名称 Medicinal Chemistry 所属学科 药学 医18药学3 教材名称 Foye's Principles of Medicinal Chemistry, 7th edition 授课年级 (全英文方 向) Chapter 11.Serotonin Trceptors and 授课章节 Drugs Affecting Serotonergic 授课时间 2课时 Neurotransmission 一、 教学目标：含知识目标、技能（能力）目标 1.知识目标： (1)Get a general idea about serotonin and serotonergic receptors;Understand the development history of drugs affecting serotonergic neurotransmission; (2)To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major drugs affecting serotonergic neurotransmission; (3) Understand the synthesis and metabolism of major drugs affecting serotonergic neurotransmission 2.技能（能力）目标：结合实验课程目标
苏州大学医学部药学院授课教案 授课教师： 叶娜 授课日期：2020.9.29 课程名称 Medicinal Chemistry 所属学科 药学 教材名称 Foye’s Principles of Medicinal Chemistry, 7th edition 授课年级 医 18 药学 3 （全英文方 向） 授课章节 Chapter 11. Serotonin Trceptors and Drugs Affecting Serotonergic Neurotransmission 授课时间 2 课时 一、 教学目标：含知识目标、技能（能力）目标 1. 知识目标： （1） Get a general idea about serotonin and serotonergic receptors; Understand the development history of drugs affecting serotonergic neurotransmission; （2） To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major drugs affecting serotonergic neurotransmission; （3） Understand the synthesis and metabolism of major drugs affecting serotonergic neurotransmission 2. 技能（能力）目标：结合实验课程目标
二 授课内容（依据教学大纲）及时间分配 Get a general idea about serotonin and its functions and neurochemistry 8min Get a general idea about the distribution,structures and functions of serotonin receptor 7 min Get a general idea about drugs affecting serotonergic neurotransmission. 5min To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major drugs affecting serotonergic neurotransmission;Understand the synthesis and metabolism of major drugs affecting serotonergic neurotransmission Including the following specific drugs(80 min): 5-HT1A Receptor Agonists:Buspirone,gepirone,ipsapirone; Vilazodone 10 min 5-HT1D Agonists:Sumatriptan 10 min 5-HT1F Agonists:Lasmiditan 10 min Selective inverse 5-HT2A agonist:pimavanserin 10min 5-HT2B agonist:fenfluramine/phentermine 10 min 5-HT2C agonist:lorcaserin 10 min 5-HT2C antagonist:Agomelatine 10 min 5-HT-3 Receptor Antagonists:Ondansetron 10 min 三、 教学重点与难点 1.教学重点 Drug discovery and design,chemical structures,structure-activity relationships,and
二、 授课内容（依据教学大纲）及时间分配 Get a general idea about serotonin and its functions and neurochemistry 8 min Get a general idea about the distribution, structures and functions of serotonin receptor 7 min Get a general idea about drugs affecting serotonergic neurotransmission. 5 min To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major drugs affecting serotonergic neurotransmission; Understand the synthesis and metabolism of major drugs affecting serotonergic neurotransmission Including the following specific drugs (80 min): 5-HT1A Receptor Agonists: Buspirone, gepirone, ipsapirone; Vilazodone 10 min 5-HT1D Agonists: Sumatriptan 10 min 5-HT1F Agonists: Lasmiditan 10 min Selective inverse 5-HT2A agonist: pimavanserin 10 min 5-HT2B agonist: fenfluramine/phentermine 10 min 5-HT2C agonist: lorcaserin 10 min 5-HT2C antagonist: Agomelatine 10 min 5-HT-3 Receptor Antagonists: Ondansetron 10 min 三、 教学重点与难点 1. 教学重点 Drug discovery and design, chemical structures, structure-activity relationships, and