苏州大学医学部药学院授课教案 授课教师：叶娜 授课日期：2020.9.24 课程名称 Medicinal Chemistry 所属学科 药学 医18药学3 教材名称 Foye's Principles of Medicinal Chemistry, 7th edition 授课年级 (全英文方 向) 授课章节 Chapter 9.Drugs Affecting Cholinergic Neurotransmission 授课时间 2课时 一、 教学目标：含知识目标、技能（能力）目标 1.知识目标： (1)Get a general idea about acetylcholine and cholinergic receptors; Understand the development history of drugs affecting cholinergic neurotransmission; (2)To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major drugs affecting cholinergic neurotransmission; (3) Understand the synthesis and metabolism of major drugs affecting cholinergic neurotransmission 2.技能（能力）目标：结合实验课程目标
苏州大学医学部药学院授课教案 授课教师： 叶娜 授课日期：2020.9.24 课程名称 Medicinal Chemistry 所属学科 药学 教材名称 Foye’s Principles of Medicinal Chemistry, 7th edition 授课年级 医 18 药学 3 （全英文方 向） 授课章节 Chapter 9. Drugs Affecting Cholinergic Neurotransmission 授课时间 2 课时 一、 教学目标：含知识目标、技能（能力）目标 1. 知识目标： （1） Get a general idea about acetylcholine and cholinergic receptors; Understand the development history of drugs affecting cholinergic neurotransmission; （2） To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major drugs affecting cholinergic neurotransmission; （3） Understand the synthesis and metabolism of major drugs affecting cholinergic neurotransmission 2. 技能（能力）目标：结合实验课程目标
二 授课内容（依据教学大纲）及时间分配 Get a general idea about neurotransmitters and associated neuropsychiatric disease 7min Get a general idea about acetylcholine and its functions and neurochemistry 8min Get a general idea about the distribution,structures and functions of cholinergic receptors 8min Get a general idea about Alzheimer disease 7min To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major cholinergic drugs; Understand the synthesis and metabolism of major cholinergic drugs Including the following specific drugs(70 min): Muscarinic Agonists:Methacholine Chloride;Carbachol;Bethanechol Chloride;Pilocarpine;Cevimeline 20 min Acetylcholinesterase Inhibitors:Neostigmine;Rivastigmine;Tacrine; Galantamine;Donepezil; 25 min Muscarinic Antagonists:Atropine and its Analogues;Tiotropium bromide;Artane;Benztropine. 25min 三、 教学重点与难点 1.教学重点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major cholinergic drugs
二、 授课内容（依据教学大纲）及时间分配 Get a general idea about neurotransmitters and associated neuropsychiatric disease 7 min Get a general idea about acetylcholine and its functions and neurochemistry 8 min Get a general idea about the distribution, structures and functions of cholinergic receptors 8 min Get a general idea about Alzheimer disease 7 min To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major cholinergic drugs; Understand the synthesis and metabolism of major cholinergic drugs Including the following specific drugs (70 min): Muscarinic Agonists: Methacholine Chloride; Carbachol; Bethanechol Chloride; Pilocarpine; Cevimeline 20 min Acetylcholinesterase Inhibitors: Neostigmine; Rivastigmine; Tacrine; Galantamine; Donepezil; 25 min Muscarinic Antagonists: Atropine and its Analogues; Tiotropium bromide; Artane; Benztropine. 25 min 三、 教学重点与难点 1. 教学重点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major cholinergic drugs
2.教学难点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major cholinergic drugs 四、 教学方法选择 3.理论课堂教学 A.多媒体教学： (简要列出本章节多媒体教学设计特点及优势) B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题) 4.实验教学： (简要列出实验内容标题) 五、 更新或补充内容提要
2. 教学难点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major cholinergic drugs 四、 教学方法选择 3. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题） 4. 实验教学：（简要列出实验内容标题） 五、 更新或补充内容提要
六 复习思考题 Write down the chemical structual of acetylcholine.Can patients with deficiencies in acetylcholine could be treated by administering acetylcholine itself?Why? 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期肝刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
六、 复习思考题 Write down the chemical structual of acetylcholine. Can patients with deficiencies in acetylcholine could be treated by administering acetylcholine itself? Why? 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
苏州大学医学部药学院授课教案 授课教师：叶娜 授课日期：2020.9.25 课程名称 Medicinal Chemistry 所属学科 药学 医18药学3 教材名称 Foye's Principles of Medicinal Chemistry, 7th edition 授课年级 (全英文方 向) Chapter 10.Adrenergic Receptors and 授课章节 Drugs Affecting Adrenergic 授课时间 2课时 Neurotransmission 一、 教学目标：含知识目标、技能（能力）目标 3.知识目标： (1) Get a general idea about adrenaline and adrenergic receptors;Understand the development history of drugs affecting adrenergic neurotransmission; (2) To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major drugs affecting adrenergic neurotransmission; (3)Understand the synthesis and metabolism of major drugs affecting adrenergic neurotransmission 4.技能（能力）目标：结合实验课程目标
苏州大学医学部药学院授课教案 授课教师： 叶娜 授课日期：2020.9.25 课程名称 Medicinal Chemistry 所属学科 药学 教材名称 Foye’s Principles of Medicinal Chemistry, 7th edition 授课年级 医 18 药学 3 （全英文方 向） 授课章节 Chapter 10. Adrenergic Receptors and Drugs Affecting Adrenergic Neurotransmission 授课时间 2 课时 一、 教学目标：含知识目标、技能（能力）目标 3. 知识目标： （1） Get a general idea about adrenaline and adrenergic receptors; Understand the development history of drugs affecting adrenergic neurotransmission; （2） To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major drugs affecting adrenergic neurotransmission; （3） Understand the synthesis and metabolism of major drugs affecting adrenergic neurotransmission 4. 技能（能力）目标：结合实验课程目标