mechanism of actions of major serotonergic drugs 2.教学难点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major serotonergic drugs 四、 教学方法选择 7.理论课堂教学 A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题)】 8.实验教学： (简要列出实验内容标题)
mechanism of actions of major serotonergic drugs 2. 教学难点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major serotonergic drugs 四、 教学方法选择 7. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题） 8. 实验教学：（简要列出实验内容标题）
五、 更新或补充内容提要 六、 复习思考题 In serotonin receptors,activation of which of the following targets may lead to valvular heart disease? Which is the "gold standard"for treatment of chemotherapy-and radiation- induced nausea and vomiting Serotonin is an extremely important neuro-transmitter.Please write the detailed biochemistry of serotonin,including how it is biosynthesized and metabolized 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期干刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
五、 更新或补充内容提要 六、 复习思考题 In serotonin receptors, activation of which of the following targets may lead to valvular heart disease? Which is the “gold standard” for treatment of chemotherapy- and radiationinduced nausea and vomiting Serotonin is an extremely important neuro-transmitter. Please write the detailed biochemistry of serotonin, including how it is biosynthesized and metabolized 七、 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 《药物化学》尤启冬主编，化学工业出版社，第三版
苏州大学医学部药学院授课教案 授课教师：叶娜 授课日期：2020.10.9 课程名称 Medicinal Chemistry 所属学科 药学 医18药学3 教材名称 Foye's Principles of Medicinal Chemistry, 7th edition 授课年级 (全英文方 向) Chapter 13.Drugs used to Treat 授课章节 Neuromuscular Disorders: 授课时间 2课时 Antiparkinsonian Agents 教学目标：含知识目标、技能（能力）目标 1.知识目标： (1)Get a general idea about Parkinson'diseases,Understand the development history of antiparkinsonian drugs; (2)To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major antiparkinsonian drugs; (3)Understand the synthesis and metabolism of antiparkinsonian drugs. 2.技能（能力）目标：结合实验课程目标
苏州大学医学部药学院授课教案 授课教师： 叶娜 授课日期：2020.10.9 课程名称 Medicinal Chemistry 所属学科 药学 教材名称 Foye’s Principles of Medicinal Chemistry, 7th edition 授课年级 医 18 药学 3 （全英文方 向） 授课章节 Chapter 13. Drugs used to Treat Neuromuscular Disorders: Antiparkinsonian Agents 授课时间 2 课时 一、 教学目标：含知识目标、技能（能力）目标 1. 知识目标： （1） Get a general idea about Parkinson’diseases, Understand the development history of antiparkinsonian drugs; （2） To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major antiparkinsonian drugs; （3） Understand the synthesis and metabolism of antiparkinsonian drugs. 2. 技能（能力）目标：结合实验课程目标
二 授课内容（依据教学大纲）及时间分配 Get a general idea about Parkinson'diseases 10 min Get a general idea about dopamine and its functions and neurochemistry 15 min Get a general idea about the distribution,structures and functions of dopamine receptor. 10 min To master the chemical structures,drug design,structure-activity relationships,and mechanism of actions of major antiparkinsonian drugs;Understand the synthesis and metabolism of antiparkinsonian drugs. Including the following specific drugs(65 min): Dopamine replacement:L-DOPA,carbidopa,Tolcapone,Selegiline, Rasagiline;Safinamide 25 min Dopamine Receptor Agonists:apomorphine,pramipexole,ropinirole 20 min Drugs Indirectly Target Dopamine System:Amantadine,Artane, Rivastigmine,Istradefylline 20 min 三、 教学重点与难点 1.教学重点 Drug discovery and design,chemical structures,structure-activity relationships,and mechanism of actions of major antiparkinsonian agents 2.教学难点 Drug discovery and design,chemical structures,structure-activity relationships,and
二、 授课内容（依据教学大纲）及时间分配 Get a general idea about Parkinson’ diseases 10 min Get a general idea about dopamine and its functions and neurochemistry 15 min Get a general idea about the distribution, structures and functions of dopamine receptor. 10 min To master the chemical structures, drug design, structure-activity relationships, and mechanism of actions of major antiparkinsonian drugs; Understand the synthesis and metabolism of antiparkinsonian drugs. Including the following specific drugs (65 min): Dopamine replacement: L-DOPA, carbidopa, Tolcapone, Selegiline, Rasagiline; Safinamide 25 min Dopamine Receptor Agonists: apomorphine, pramipexole, ropinirole 20 min Drugs Indirectly Target Dopamine System: Amantadine, Artane, Rivastigmine, Istradefylline 20 min 三、 教学重点与难点 1. 教学重点 Drug discovery and design, chemical structures, structure-activity relationships, and mechanism of actions of major antiparkinsonian agents 2. 教学难点 Drug discovery and design, chemical structures, structure-activity relationships, and
mechanism of actions of major antiparkinsonian agents 四、 教学方法选择 9.理论课堂教学 A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题) 10.实验教学： (简要列出实验内容标题) 五、 更新或补充内容提要
mechanism of actions of major antiparkinsonian agents 四、 教学方法选择 9. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂 等互动教学内容标题） 10. 实验教学：（简要列出实验内容标题） 五、 更新或补充内容提要