Therapeutic drugs for Hypothyroidism antithyroid drugs: thiourea derivatives iodine and iodides B receptor antagonists surgery radioiodines: 131. 125I
B. Antithyroid drugs a Thiourea derivatives Propylthiouracil丙硫氧嘧啶 Methimazole( tapazole)甲巯咪唑 Carbimazole卡比马唑 a lodine and iodides B Receptor antagonists Radioiodide(31
THYROID GLAND Transport Peroxidase Thyroglobulin MIT-DIT-T3Te lodides Proteolysis lodides thioamides SCN CIO TT PERIPHERAL BLOOD TISSUES 4T3 ipodate corticosteroids
B. Antithyroid drugs Thiourea derivatives Propylthiouracil Methimazole Carbimazole CH3 CH3 CH3CH2CH2、N少S N/SH 丙硫氧嘧啶 甲巯咪唑 COOCh Thiamazole 卡比马唑
B. Antithyroid drugs a Thiourea derivatives 1. Pharmacological effects (1) Inhibiting the formation of thyroid hormones by interfering with iodination: inhibiting peroxidation then the iodination and coupling Symptom relieving: 2-3 weeks Basic metabolic rate returning: 1-2 months (2) Inibiting peripheral deiodination ofT T4 T3k (propylthiouracil) (3)Goitrogenic action(goiter): TSH 1