TPO g TPo g METABOLIC STEP INHIBITOR g HOI a lodide transport CIO, SCN- lumen B lodination PTU MMI EO C Coupling PTU MMI D Colloid resorption Colchicine Li2+,I- Cytochalasin B E Proteolysis 00d F Deiodination of DIT Mit Dinitrotyrosine PTU apical membrane G Deiodination of T4 cel Follicular LE MIT DIT. 5.de- iodinate 4 GT3 Follicular lumen containing Tg ECF A basement membrane - Metabolism of thyroid hormones
NH 2 ● CH.-CH-COOH L-tyrosine Ho一 CH.-CH-COOH CH.-CH-COOH monoiodotyrosine(MIT) diiodotyrosine(DIT) HO CH2-CH-COOHHO R 3,5,3-triodothyronine ( T3) Formation of NH 2 thyroxine(T,) and -CH 2-CH-COOH triiodothyronine(T3) from iodotyrosine 3, 5,3,5,tetraiodothyronine(Ta) ( thyroxine
Lumen Storage area MIT Apical cell I+Tg T Secretion of thyroid hormones( lysosomal Sydrome proteolytic enzymes) Golgi 0 0 Endoplasmic TA Nucleus Basement Bloodstream
Circadian and psychosis pulsatile rhythms Severe Cold v stress H Hypothalamus Somato Corticoids or ITRI dopamine Regulation of the AP T4,T3 secretion of thyroid hormones(feedback TSH团 inhibition) roid
Pharmacology of thyroid hormones a 1. Normalizing growth and development 2. Promoting body metabolism Body temperature; energy levels, ect. 3. Enhancing sympathetic activity