Stria vascularis 血管纹 前庭阶 Scala vestibuli Scala media 中阶；蜗管 Ductus cochlearis 2b Limulus 9 87 6 10 Scala tympani 鼓阶
前庭阶 血管纹 鼓阶 中阶；蜗管
Nerve Terminal synaptic vesicles with acetyl choline active zones acetyl choline receptors junctional fold ion channels Striated Muscle Cell NEUROMUSCULAR JUNCTION
Aminoglycosides 。Mechanism: binding to the S12 Protein of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl- methionyI-tRNA to the 30S subunit
Aminoglycosides • Mechanism: binding to the S12 Protein of the 30S subunit of the bacterial ribosome, interfering with the binding of formylmethionyl-tRNA to the 30S subunit
Inhibition of Protein Synthesis by Antibiotics Chloramphenicol Growing peptide binds to 508 r-RNA and inhibits formation of peptide bond 506 portion r-RNA Erythromycin +-RNA binds to 508 r-RNA and prevents movement along m-RNA m-RNA 305 portion Streptomycin Tetracycline changes shape of 30S interfers with the t-RNA r-RNA and causes m-RNA anticodon reading of to be read incorrectly m-RNA codon C.Ophardt,c.2003
Resistance to aminoglycosides Aminoglycoside-modifying enzymes (钝化酶) √Phosphoryltransferases(磷酰转移酶) √Acetyltransferases（乙酰转移酶) √Adeny小yltransferases(腺苷酰转移酶)
Resistance to aminoglycosides Aminoglycoside-modifying enzymes (钝化酶) Phosphoryltransferases（磷酰转移酶） Acetyltransferases（乙酰转移酶） Adenylyltransferases（腺苷酰转移酶）