Fortimicin A+Acetyl-CoACoASH+Acetylated fortimicin A AAC3)-Ib/AAC6)-Ib OH 6 HO NH +Acetyl-CoA CoASH+ 一NH N性 NH OH LOH -oh
Polymyxins (多黏菌素)
Polymyxins (多黏菌素 )
Polymyxins(多粘菌素类) HO OH HN HN NH NH2 Cyclic peptide with a long hydrophobic tail
Polymyxins（多粘菌素类） Cyclic peptide with a long hydrophobic tail
Polymyxins Detergents,selectively toxic for Gram bacteria due to their specificity for the lipopolysaccharide(脂多糖)molecule o Strong nephrotoxic Renewed interest duo to antimicrobial resistance
Polymyxins • Detergents, selectively toxic for Grambacteria due to their specificity for the lipopolysaccharide（脂多糖） molecule • Strong nephrotoxic • Renewed interest duo to antimicrobial resistance
Macrolides (大环内酯类)
Macrolides （大环内酯类）