Individual aminoglycosides ·Streptomycin(链霉素) ·Gentamycin(庆大霉素) ·Amikacin(氨苄卡星) ·Tobramycin(妥布霉素) ·Netilmycin(奈替米星) ■
Individual aminoglycosides • Streptomycin（链霉素） • Gentamycin（庆大霉素） • Amikacin（氨苄卡星） • Tobramycin（妥布霉素） • Netilmycin（奈替米星） • …
Aminoglycosides Common characteristics: Potent effect on G bacteria,including Pseudomonas aeroginosa,Mycobacterium tuberculosis √Not absorbed orally Untoward effects:>5 days;high dose;elderly; renal insufficiency Ototoxicity(2%-10%):vertigo(眩晕)， ataxia(共济失调)，loss of banlance Nephrotoxicity (6%-10%) Neuromuscular blocking (co-administered with general analgesics or muscle relaxants)
Aminoglycosides Common characteristics: Potent effect on G- bacteria, including Pseudomonas aeroginosa, Mycobacterium tuberculosis Not absorbed orally Untoward effects: >5 days; high dose; elderly; renal insufficiency • Ototoxicity （ 2 ％-10％）: vertigo（眩晕）, ataxia（共济失调）, loss of banlance • Nephrotoxicity （ 6 ％-10％） • Neuromuscular blocking (co-administered with general analgesics or muscle relaxants)
Toxicity of aminoglycodises ● Severe ototoxicity and nephrotoxicity. 18 of 21 actresses showing "qianshou guanyin"were caused deafness by aminoglycosides
Toxicity of aminoglycodises • Severe ototoxicity and nephrotoxicity. • 18 of 21 actresses showing “qianshou guanyin” were caused deafness by aminoglycosides
A B C 78 9 10 6 11 2 3 12 5 Auricle;middle ear;inner ear
Auricle; middle ear; inner ear
anterior canal 小囊 Nerve Utricle 球囊 Saccule posterior canal horzontal canal Cochlea 耳蜗 水平半规管
耳蜗 球囊 小囊 水平半规管