a-adrenoceptor:a, receptors: postsynaptic membrane of the effector organs.especiallythevascular smooth muscle andpupillary dilatormusclea,receptors: presynaptic nerve endings and on other cellssuch as the B cell of the pancreasB-adrenoceptor:B,receptors:located primarily on heartB,receptors:bronchial and vascular smooth muscleB,receptors:lipocytes
α-adrenoceptor: α1 receptors: postsynaptic membrane of the effector organs, especially the vascular smooth muscle and pupillary dilator muscle α2 receptors: presynaptic nerve endings and on other cells, such as the ßcell of the pancreas ß–adrenoceptor: ß1 receptors: located primarily on heart ß2 receptors: bronchial and vascular smooth muscle ß3 receptors: lipocytes
C.Dopaminereceptors:D,D2,D3,D,and DtheycomprisetwoD,-like receptors(D,andD,)andthreeD,-likereceptors(D,D,and D).Dopamine receptors are particularly important in thebrain andin the splanchnic and renal vasculature
C. Dopamine receptors: D1 , D2 , D3 , D4 and D5 they comprise two D1 -like receptors(D1 and D5 ) and three D2 -like receptors(D2 , D3 and D4 ). Dopamine receptors are particularly important in the brain and in the splanchnic and renal vasculature
ADRENOCEPTORS8a2aInhibition ofVasodilationTachycardiaVasoconstrictionnorepinephrineSlightly decreasedreleaseIncreased lipolysisIncreased peripheralperipheral resistanceresistanceInhibition ofIncreased myocardialBronchodilationinsulin releasecontractilityIncreased blood pressureIncreased muscleand liverglycogenolysisMydriasisIncreasedclosure ofIncreased releaseinternal sphincter ofof glucagonthe bladderRelaxeduterinesmoothmuscle
III.Functional organization of autonomic activityA.Inbloodvesselsboth alpha and beta are present on the blood vesselsa.Alpha l:vasoconstriction (skin,brain,viscerab.Beta 2:inhibits contraction.causing vasodilation(skeletal muscle,coronarydilatation)B.intheheart:Bincrease rate of contraction (positive chronotropicIncrease force of contraction (positive inotropic)
III. Functional organization of autonomic activity A. In blood vessels both alpha and beta are present on the blood vessels a. Alpha 1: vasoconstriction ( skin ,brain, viscera) b. Beta 2: inhibits contraction, causing vasodilation (skeletal muscle ,coronary dilatation ) B. in the heart : ß1 increase rate of contraction (positive chronotropic) Increase force of contraction (positive inotropic)
C.in the lungs (bronchial smooth muscle)Beta (beta-2)stimulation--bronchodilationD.IntheeyeMR : pupillary constrictor muscle -constrictionalR:pupillary dilator muscle--dilationE.SalivaryglandsM3:Secretion
C. in the lungs (bronchial smooth muscle) Beta (beta-2) stimulation—bronchodilation D. In the eye MR ：pupillary constrictor muscle –constriction a1R ：pupillary dilator muscle-dilation E. Salivary glands M3: Secretion