5.Degradationof norepinephrine:Uptake l: reuptake into the nerve terminalsThefate of recaptured norepinephrine.i:most of them into the storage vesiclesii: these who don't into vesicles can be oxidized bymonoamineoxidase(MAO)Uptake 2:into cardiac muscle or smooth musclecells Can be metabolized by COMT and MAO
Uptake 1: reuptake into the nerve terminals The fate of recaptured norepinephrine: i: most of them into the storage vesicles ii: these who don’t into vesicles can be oxidized by monoamine oxidase(MAO). Uptake 2: into cardiac muscle or smooth muscle cells Can be metabolized by COMT and MAO. 5.Degradation of norepinephrine :
A few diffuse out of synaptic space and enterthegeneralcirculation.Cotransmitters in Cholinergic and AdrenergicNerves This phenomenon that the vesicles of bothcholinergicandadrenergicnervescontainothersubstances in addition to the primary transmitter iscalledcotransport
A few diffuse out of synaptic space and enter the general circulation. Cotransmitters in Cholinergic and Adrenergic Nerves This phenomenon that the vesicles of both cholinergic and adrenergic nerves contain other substances in addition to the primary transmitter is called cotransport
PresynapticneuronendingActionTyrosinepotentialsCa+++DopaInactivatedDopaminebyMAONorepinephrineReuptake(most)CirculationCPNorepinephrineCCOReceptorInactivatedPostsynapticbyCOMTcellInactiveproducts儿茶酚胺的产生、释放及再摄取
儿茶酚胺的产生､释放及再摄取
SYMPATHETICNERVEVARICOSITYTYROSINEEFFECTORACELLNEPFTYROSINE1esOnse?NEBDOPAPNEG￥OR.RNEEDACDCOMTNENENMNvesiclesresponseENE工心NEMBRNENEURONEMAOEFFECTORJUNCTIONThe synthesis,release,reuptake,andmetabolism of Norepinephrine
The synthesis, release, reuptake, and metabolism of Norepinephrine
B.ADRENGICRECEPTORSa-adrenoceptor:a,anda,receptorsadrenoceptorsβ-adrenoceptor:B,,B, andB,receptors
B. ADRENGIC RECEPTORS adrenoceptors α-adrenoceptor: α1 andα2 receptors ß –adrenoceptor: ß1 , ß2 and ß3 receptors