《分子生物学D》（供六年制临床医学专业来华留学生使用）教学大纲基础医学院生物化学与分子生物学教研室2021年10月
《分子生物学 D》 （供六年制临床医学专业来华留学生使用） 教 学 大 纲 基础医学院生物化学与分子生物学教研室 2021 年 10 月
Preface1.BasicinformtionName:Molecular BiologyClass hours: 36 total class hours including 27 teaching hours and 9 experimental hours.2 total credit hours.Speciality:six-year termclinical medicine specialty (foreign students)The prerequisite courses: Biology, Chemistry, Organic Chemistry and Biochemistry2.IntroductionIn a broad viewpoint, Molecular Biology concerns the understanding of biologicalphenomena in molecular terms. More restrictively, Molecular Biology refers to the study ofgene structure and function at the molecular level. Just like Biochemistry, MolecularBiology has also become the basic language of all life sciences. A thorough comprehensionof Molecular Biology will enable students to best understand the molecular basis ofdisease.Molecular Biology is an important and foundamental preclinical course for advancedmedial education. Molecular Biology lays the foundation for other basic and clinicalmedical sciences.3.ObjecttivesThe Molecular Biology course is taught at the fourth semester for internationalstudents majoring clinical medicine. This course introduces the foundations of moleculabiology and provides medical perspectives. Through this ourse, students could understandthe central dogma and the common molecular technologies and methods. Through thiscourse study, students will understand the basis of disease developement and try to explorethemolecularmechnism of somediseases.4.RequimentsThe recommended textbook is Lippincott's Illustrated Reviews: Biochemistry (6thedition). This teaching outline is mainly constituted based on China National MedicalLicensing Examination (CNMLE) and United States Medical Licensing Examination(USMLE). The teaching aims and requirements for each chapter are mainly set up at three
Preface 1. Basic informtion Name: Molecular Biology Class hours: 36 total class hours including 27 teaching hours and 9 experimental hours. 2 total credit hours. Speciality: six-year term clinical medicine specialty (foreign students) The prerequisite courses: Biology, Chemistry, Organic Chemistry and Biochemistry. 2. Introduction In a broad viewpoint, Molecular Biology concerns the understanding of biological phenomena in molecular terms. More restrictively, Molecular Biology refers to the study of gene structure and function at the molecular level. Just like Biochemistry, Molecular Biology has also become the basic language of all life sciences. A thorough comprehension of Molecular Biology will enable students to best understand the molecular basis of disease. Molecular Biology is an important and foundamental preclinical course for advanced medial education. Molecular Biology lays the foundation for other basic and clinical medical sciences. 3. Objecttives The Molecular Biology course is taught at the fourth semester for international students majoring clinical medicine. This course introduces the foundations of molecular biology and provides medical perspectives. Through this ourse, students could understand the central dogma and the common molecular technologies and methods. Through this course study, students will understand the basis of disease developement and try to explore the molecular mechnism of some diseases. 4. Requiments The recommended textbook is Lippincott's Illustrated Reviews: Biochemistry (6th edition). This teaching outline is mainly constituted based on China National Medical Licensing Examination (CNMLE) and United States Medical Licensing Examination (USMLE). The teaching aims and requirements for each chapter are mainly set up at three
differentlevels(Understand>Befamiliar with>Beawareof)5.MethodsThis course will be taught mainly by Lecture with Multimedia. Students can learn partofchapterbyself-studyorgroupdiscussion6.EvaluationWeiEvaluationEvaluationEvaluation standardsItemghtabilityindicatorOnline learning activity in Umooc:E-learningSelf-studyPrepare(100 points)ability,1. Online length (5%) (100 points):lessionby33.3Analyzing-pro≥100 minutes, 100 points; <100, 11. Online lengthwatchingblem ability,points per time%2NumberofvideosandSolving-probl2.Numberofvideos/PPTsofcoursePPTsvideos/PPTs ofem ability(5%) (100 points) :≥10 times, 100course<10,0pointspoints,AnalyzingOnlineMasterand33.4andsolvingTests/quizzes in Umooc.useoftests/quizzes%problemAverage of these tests scores.Formatiknowledge(100 points )abilityveCorrectevaluatiexperimentalAnalyzingonandoperationsolving(E-learExperimentsandhomeworksinExperiments andandseriousproblemning and33.3Umoochomeworksexperimentalability,tests)%Two experimental reports, and I~2report,experimental(30%)(100 points )homeworks.Average of these scores.MasterandoperationUMOOCskills.useofknowledgeTake part in the course discussion areaPostand in Umooc:replyAnalyzingBonusNumber of posts ≥10 times, 3 points;questions inandsolvingtheproblemcourse(6 points)1~9 times, 2 pointsdiscussionabilityNumber of replies ≥10 times, 3 points;area1~9 times, 2 pointsSummarizedevaluatiAnalyzingonMasterand100Final examandsolving(FinaluseofFinal exam online(100 points)%problemexam)knowledgeability(70%)ExamonlineParticipant:Xianjun Liu, Faping Yi, Xue Jiang,Youquan BuWriter:Huifang ZhuAssessor:YouquanBu
different levels (Understand > Be familiar with > Be aware of). 5. Methods This course will be taught mainly by Lecture with Multimedia. Students can learn part of chapter by self-study or group discussion. 6. Evaluation Participant：Xianjun Liu, Faping Yi, Xue Jiang, Youquan Bu Writer：Huifang Zhu Assessor：Youquan Bu Item Wei ght Evaluation indicator Evaluation ability Evaluation standards Formati ve evaluati on （E-lear ning and tests） （30%） UMOOC E-learning (100 points) 1. Online length 2 Number of videos/PPTs of course 33.3 % Prepare lession by watching videos and PPTs Self-study ability, Analyzing-pro blem ability, Solving-probl em ability Online learning activity in Umooc： 1. Online length (5%) (100 points): ≥100 minutes, 100 points; <100, 1 points per time 2. Number of videos/PPTs of course (5%) (100 points) : ≥10 times, 100 points; <10, 0 points Online tests/quizzes (100 points ) 33.4 % Master and use of knowledge Analyzing and solving problem ability Tests/quizzes in Umooc. Average of these tests scores. Experiments and homeworks (100 points ) 33.3 % Correct experimental operation and serious experimental report, Master and use of knowledge Analyzing and solving problem ability, experimental operation skills. Experiments and homeworks in Umooc: Two experimental reports, and 1~2 homeworks. Average of these scores. Bonus (6 points) Post and reply questions in the course discussion area Analyzing and solving problem ability Take part in the course discussion area in Umooc: Number of posts ≥10 times, 3 points; 1~9 times, 2 points Number of replies ≥10 times, 3 points; 1~9 times, 2 points Summar ized evaluati on （Final exam） （70%） Exam online Final exam (100 points ) 100 % Master and use of knowledge Analyzing and solving problem ability Final exam online
Textbook, Teaching auxiliary books and BibliographyThis teaching outline is mainly constituted based on China National MedicalLicensing Examination (CNMLE) and United States Medical Licensing Examination(USMLE). So we choose Lippincott's Illustrated Reviews: Biochemistry (6th edition), aclassic common book as the textbook.1.TextbookDenise R. Ferrier. Lippincott's Illustrated Reviews: Biochemistry (6th).Baltimore:WoltersKluwer, Lippincott Williams&Wilkins,2014.2.TeachingauxiliarybooksYouquan Bu. Molecular Biology, Learning Guidelines & Self-Tests. (unpublishedbook)3.Bibliography(I) Michael A. Lieberman, Rick Ricer. Lippincott's illustrated Q & A review ofbiochemistry, 1st ed.Baltimore: Lippincott Williams & Wilkins. 2010(2) Michael A.Lieberman, Rick Ricer.BRS Biochemistry, Molecular Biology, andGenetics.Sixth Edition.Baltimore: Lippincott Williams & Wilkins.2014.(3) David L. Nelson, Michael M. Cox. Lehninger Principles of Biochemistry. 6th edNew York: W.H.Freeman and Company, 2013.(4) James D.Watson, Tania A.Baker, Stephen P. Bell, Alexander Gann, MichaelLevine, Richard Losick. Molecular Biology of the Gene. 7th ed.New York: Cold SpringHarbor Laboratory Press, 2013.(5) Victor W.Rodwell, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, P.Anthony Weil. Harper's illustrated biochemistry. 30th ed. 2015. New York. McGraw-HillCompanies.(6)RobertF.Weaver.MolecularBiology,fifthedition.2012.NewYork.McGraw-HillCompanies
Textbook, Teaching auxiliary books and Bibliography This teaching outline is mainly constituted based on China National Medical Licensing Examination (CNMLE) and United States Medical Licensing Examination (USMLE). So we choose Lippincott's Illustrated Reviews: Biochemistry (6th edition), a classic common book as the textbook. 1. Textbook Denise R. Ferrier. Lippincott's Illustrated Reviews: Biochemistry (6th). Baltimore: Wolters Kluwer, Lippincott Williams &Wilkins, 2014. 2. Teaching auxiliary books Youquan Bu. Molecular Biology, Learning Guidelines & Self-Tests. (unpublished book) 3. Bibliography (1) Michael A. Lieberman, Rick Ricer. Lippincott’s illustrated Q & A review of biochemistry, 1st ed. Baltimore: Lippincott Williams & Wilkins. 2010. (2) Michael A. Lieberman, Rick Ricer. BRS Biochemistry, Molecular Biology, and Genetics. Sixth Edition. Baltimore: Lippincott Williams & Wilkins. 2014. (3) David L. Nelson, Michael M. Cox. Lehninger Principles of Biochemistry. 6th ed. New York: W. H. Freeman and Company, 2013. (4) James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick. Molecular Biology of the Gene. 7th ed. New York: Cold Spring Harbor Laboratory Press, 2013. (5) Victor W. Rodwell, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil. Harper's illustrated biochemistry. 30th ed. 2015. New York. McGraw-Hill Companies. (6) Robert F. Weaver. Molecular Biology, fifth edition. 2012. New York. McGraw-Hill Companies
OutlinesTeaching Arrangements (36 class hours)2IntroductionChapter 1 DNA Structure, Replication, and Repair .Chapter 2 RNA Structure, Synthesis, and Processing..Chapter3Protein Synthesis.4Chapter 4 Regulation of Gene Expression....5Chapter 5Biotechnology and Human Disease..6dExperiment1PlasmidExtractionExperiment 2 PCR......8Appendix:ClinicalCase study
Outlines Teaching Arrangements (36 class hours).1 Introduction .2 Chapter 1 DNA Structure, Replication, and Repair .2 Chapter 2 RNA Structure, Synthesis, and Processing.3 Chapter 3 Protein Synthesis .4 Chapter 4 Regulation of Gene Expression.5 Chapter 5 Biotechnology and Human Disease.6 Experiment 1 Plasmid Extraction .8 Experiment 2 PCR.8 Appendix: Clinical Case study .9