Whatare the enzymes involved in biotransformation? 七、学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 朱依谆主编.药理学第八版，北京，人民卫生出版社，2019 Oxford Textbook of Clinical Pharacology and Drug Therapy David Grahame-Smith,Jeffrey Aronson.Edition:3 Clinical Pharmacology Made Incredibly Easy!(Incredibly Easy!Series) Springhouse,2008 Edition:3Rev Ed. 苏州大学医学部药学院授课教案 授课教师：秦正红授课日期：2020.09.16 课程名称 Pharmacology IV 教材名称 Basic Clinical Pharmacology,14thedition
What are the enzymes involved in biotransformation? 七、学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019 Oxford Textbook of Clinical Pharmacology and Drug Therapy David Grahame-Smith , Jeffrey Aronson. Edition: 3 Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series) Springhouse , 2008 Edition: 3Rev Ed. 苏州大学医学部药学院授课教案 授课教师：秦正红授课日期：2020.09.16 课程名称 Pharmacology IV 教材名称 Basic & Clinical Pharmacology, 14th edition
授课章节 Chapter5 Development Regulation of Drugs 1. 敦学目标：含知识目标、技能（能力）目标 1. 知识目标： (1)To learn the variations in drug responsiveness. (2)To learn the mechanisms of receptor regulation. (3)To understand the factors of geriatric considerations. (4)To understand the selectivity of drugs. 2.技能（能力）目标： 2. 授课内容（依据教学大纲）及时间分配 1.Variations in drug responsiveness:alteration in concentration of drug that reachesthe receptor,variations in concentrat ion ofan endogenous receptor ligand;alterations in num 2.Receptor regulation:synthesis and degradation,covalent modification,association with other regulatory proteins,relocalization within the cell;be subject to feedback by their 3.Geriatric considerations:decreasing oral absorption;decreasingplasma protein concentration;decreasingmuscle mass;inc reasing body fat;decreasing liver/renal function;mu 4.Selectivity of drug:drugs are only selective-rather than specific-in their actions;selectivity can be measured by comparingbinding affinities of a drug to different receptors c effects versus toxic effects.[10 min] 三、教学重点与难点 1.教学重点 Variations in drug responsiveness:alteration in concentration ofdrug that reaches the receptor,variations in concentration of an endogenous receptor ligand;alterations in numbe
授课章节 Chapter 5 Development & Regulation of Drugs 1. 教学目标：含知识目标、技能（能力）目标 1. 知识目标： (1) To learn the variations in drug responsiveness. (2) To learn the mechanisms of receptor regulation. (3) To understand the factors of geriatric considerations. (4) To understand the selectivity of drugs. 2.技能（能力）目标： 2. 授课内容（依据教学大纲）及时间分配 1. Variations in drug responsiveness: alteration in concentration of drug that reaches the receptor; variations in concentrat ion of an endogenous receptor ligand; alterations in number or function of receptors; changes in components of response distal to the receptor. [10 min] 2. Receptor regulation: synthesis and degradation, covalent modification, association with other regulatory proteins, relocalization within the cell; be subject to feedback by their own signaling outputs. [10 min] 3. Geriatric considerations: decreasing oral absorption; decreasing plasma protein concentration; decreasing muscle mass; inc reasing body fat; decreasing liver/renal function; multiple drugs; multiple diseases. [10 min] 4. Selectivity of drug: drugs a re only selective - rather than specific - in their actions; selectivity can be measured by comparing binding affinities of a drug to different receptors or by comparin g ED50s for different effects of a drug in vivo; in drug development and in clinical medicine, selectivity is usually considered by separating effects into two categories: beneficial or therapeutic effects versus toxic effects. [10 min] 三、教学重点与难点 1.教学重点 Variations in drug responsiveness: alteration in concentration of drug that reaches the receptor; variations in concentration of an endogenous receptor ligand; alterations in number or function of rece ptors; changes in components of response distal to the receptor
2.教学难点 Receptorregulation:synthesis and degradation,covalent modification,association with other regulatory proteins,relocalization within the cell;be subject to feedback by their ow 四、教学方法选择 1.理论课堂教学 A多媒体教学：（简要列出本章节多媒体教学设计特点及优势） By using multimedia including PPT,cartoon,video in the teaching leaming process,we convey vast information and provide many sources from which student can access the inf on in dynamic environment. B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） Why is biotransformation necessary for some drugs? Where does drug biotransformation occur? 2.实验教学：（简要列出实验内容标题） 五、更新或补充内容提要
2.教学难点 Receptor regulation: synthesis and degradation, covalent modification, association with other regulatory proteins, relocalization within the cell; be subject to feedback by their own signaling outputs. 四、教学方法选择 1. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） By using multimedia including PPT, cartoon, video in the teachinglearning process, we convey vast information and provide many sourcesfrom which student can accessthe information.The Multimedia approach may improve the teachinglearning process, provide the opportunity for the studentsto gain mastery of competencies and skills, and enable the studentsto get access to informati on in dynamic environment. B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） Why is biotransformation necessary for some drugs? Where does drug biotransformation occur? 2. 实验教学：（简要列出实验内容标题） 五、更新或补充内容提要
六、复习思考题 What is the majorrole of biotransformation? Whatare the enzymes involved in biotransformation? 七、学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 朱依谆主编药理学第八版，北京，人民卫生出版社，2019 Oxford Textbook of Clinical Pharmacology and Drug Therapy David Grahame-Smith.Jeffrev Aronson.Edition:3 Clinical Pharmacology Made Incredibly Easy!(Incredibly Easy!Series) Springhouse,2008 Edition:3Rev Ed
六、复习思考题 What is the major role of biotransformation? What are the enzymes involved in biotransformation? 七、学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019 Oxford Textbook of Clinical Pharmacology and Drug Therapy David Grahame-Smith , Jeffrey Aronson. Edition: 3 Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series) Springhouse , 2008 Edition: 3Rev Ed
苏州大学医学部药学院授课教案
苏州大学医学部药学院授课教案