6.The hepatic first-pass effect can be avoided by use of sublingual tablets,transdermalpreparations,rectalsuppositories and inhalation preparations.[4 min] 7.The route and the characteristics of injection,inhalation,transdermaladministration,and local administration.[4 min] 8.The significance of plasma protein binding and physiological barriers.[7 min] 9.Basic concepts of pharmacokineticsand time-concentration curve.[10 min] 10.Pharmacokinetic parameters including Tmax,Cmax,apparent volume ofdistribution(Vd),elimination rate constant(k),halftime(t1/2),area under the curve(AUC),bioava 12.Etiological therapy and symptomatic therapy.[10 min] 3. 敦学重点与难点 1. 教学重点 The hepatic first-pass effect can be avoided by use of sublingual tablets,transdermal preparations,rectal suppositories and inhalation preparations. 2. 教学难点 Effect of pH on the rate of simple diffusion. 4. 教学方法选择
6. The hepatic first-pass effect can be avoided by use of sublingual tablets, transdermal preparations, rectal suppositories and inhalation preparations. [4 min] 7. The route and the characteristics of injection, inhalation, transdermal administration, and local administration. [4 min] 8.The significance of plasma protein binding and physiological barriers. [7 min] 9. Basic concepts of pharmacokinetics and time-concentration curve. [10 min] 10. Pharmacokinetic parameters including Tmax, Cmax, apparent volume of distribution (Vd), elimination rate constant (k), half time (t1/2), area under the curve (AUC), bioavailability (F), and clearance (CL). [16 min] 12. Etiological therapy and symptomatic therapy. [10 min] 3. 教学重点与难点 1. 教学重点 The hepatic first-pass effect can be avoided by use of sublingual tablets, transdermal preparations, rectal suppositories and inhalation preparations. 2. 教学难点 Effect of pH on the rate of simple diffusion. 4. 教学方法选择
1. 理论课堂教学 A多媒体教学：（简要列出本章节多媒体教学设计特点及优势） By using multimedia including PPT,cartoon,video in the teaching leaming process,we convey vast information and provide many sources from which student can access the inf on in dynamic environment. B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） (1).According to Dm and DL,how to design the administration strategy? (2).The processes of drug metabolism. 2. 实验教学：（简要列出实验内容标题） 5. 更新或补充内容提要 6. 复习思考题 1.What does first passelimination mean?
1. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） By using multimedia including PPT, cartoon, video in the teachinglearning process, we convey vast information and provide many sourcesfrom which student can accessthe information.The Multimedia approach may improve the teachinglearning process, provide the opportunity for the studentsto gain mastery of competencies and skills, and enable the studentsto get access to informati on in dynamic environment. B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） (1). According to Dm and DL, how to design the administration strategy? (2). The processes of drug metabolism. 2. 实验教学：（简要列出实验内容标题） 5. 更新或补充内容提要 6. 复习思考题 1. What does first pass elimination mean?
2.According to the elimination kinetics of drugs,how to guide the rationaladministration? 3.How to use the index (Tmax,Cmax,AUC,F)to evaluate the quantity ofthe drugs? 7. 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 朱依谆主编.药理学第八版，北京，人民卫生出版社，2019 Oxford Textbook of Clinical Pharmacology and Drug Therapy David Grahame-Smith,Jeffrey Aronson.Edition:3 Clinical Pharmacology Made Incredibly Easy!(Incredibly Easy!Series) Springhouse,2008 Edition:3Rev Ed. 苏州大学医学部药学院授课教案 授课教师：秦正红授课日期：2020.09.15 课程名称 Pharmacology IV 教材名称 Basic Clinical Pharmacology,14thedition
2. According to the elimination kinetics of drugs, how to guide the rational administration? 3. How to use the index (Tmax, Cmax, AUC, F) to evaluate the quantity of the drugs? 7. 学习资源、课外自主学习参考 (可以列出供学生进一步学习、拓展本章节内容的网站、著作、期刊的名称及内容等) 朱依谆主编. 药理学第八版, 北京, 人民卫生出版社, 2019 Oxford Textbook of Clinical Pharmacology and Drug Therapy David Grahame-Smith , Jeffrey Aronson. Edition: 3 Clinical Pharmacology Made Incredibly Easy! (Incredibly Easy! Series) Springhouse , 2008 Edition: 3Rev Ed. 苏州大学医学部药学院授课教案 授课教师：秦正红授课日期：2020.09.15 课程名称 Pharmacology IV 教材名称 Basic & Clinical Pharmacology, 14th edition
授课章节 Chapter4 Drug Biotransformation 1. 敦学目标：含知识目标、技能（能力）目标 1. 知识目标： (1)To learn the key procedures of drug biotransformation. (2)To learn the roles of biotransformation in drug disposition. (3)To learn the major organs where drug biotransformation occurs. (4)To understand the enzymes involved in biotransformation. 技能（能力）目标： 2. 授课内容（依据教学大纲）及时间分配 1.The roles ofbiotransformation.[20 min] 2.Human Liver P450 Enzymes.[30 min] Induction inhibition of P450. 3.Toxicity of Acetaminophen.[30 min] 三、教学重点与难点 1教学重点 Human Liver P450 Enzymes 2.教学难点 Induction inhibition of P450
授课章节 Chapter 4 Drug Biotransformation 1. 教学目标：含知识目标、技能（能力）目标 1. 知识目标： (1) To learn the key procedures of drug biotransformation. (2) To learn the roles of biotransformation in drug disposition. (3) To learn the major organs where drug biotransformation occurs. (4) To understand the enzymes involved in biotransformation. 技能（能力）目标： 2. 授课内容（依据教学大纲）及时间分配 1. The roles of biotransformation. [20 min] 2. Human Liver P450 Enzymes. [30 min] Induction & inhibition of P450. 3. Toxicity of Acetaminophen. [30 min] 三、教学重点与难点 1.教学重点 Human Liver P450 Enzymes 2.教学难点 Induction & inhibition of P450
四、教学方法选择 1.理论课堂教学 A多媒体教学：（简要列出本章节多媒体教学设计特点及优势） By using multimedia including PPT,cartoon,video in the teaching leaming process,we convey vast information and provide many sources from which student can access the inf on in dynamic environment. B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） Why is biotransformation necessary for some drugs? Where does drug biotransformation occur? 2.实验教学：（简要列出实验内容标题） 五、更新或补充内容提要 六、复习思考愿 What is the majorroles ofbiotransformation?
四、教学方法选择 1. 理论课堂教学 A. 多媒体教学：（简要列出本章节多媒体教学设计特点及优势） By using multimedia including PPT, cartoon, video in the teachinglearning process, we convey vast information and provide many sourcesfrom which student can accessthe information.The Multimedia approach may improve the teachinglearning process, provide the opportunity for the studentsto gain mastery of competencies and skills, and enable the studentsto get access to informati on in dynamic environment. B. 互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） Why is biotransformation necessary for some drugs? Where does drug biotransformation occur? 2. 实验教学：（简要列出实验内容标题） 五、更新或补充内容提要 六、复习思考题 What is the major roles of biotransformation?