5 .vessels At normal dose: little effect At large dose: dilate Mechanism (1Direct effect (2)Compensative reaction by TC rise Uses: infective shock Side reactions: flush skin
5.vessels: ❖ At normal dose: little effect ❖ At large dose: dilate Mechanism: ❖ (1) Direct effect ❖ (2) Compensative reaction by T℃ rise Uses: infective shock Side reactions: flush skin
6. CNS: a In clinical doses. minimal stimulant effects on cns a In toxic doses Excited(excitement, anxiety, delirium, hallucinations, convulsions) depression(coma)
6. CNS: ◼ In clinical doses, minimal stimulant effects on CNS ◼ In toxic doses ❖ Excited (excitement, anxiety, delirium, hallucinations, convulsions) →depression (coma)
Hallucinations and >10.0mg delirium: coma Rapid heart rate; palpitation 85.0 mg marked dryness of mouth; dilation of pupil; some blurring of near vision 2.0 mg 0.5mg Slight cardiac slowing; some dryness of the mouth; inhibition of sweating gure 5. 4 Dose-dependent effects of atropine