AnalgesicEffectsPain mayarise from:Musculature,dentalworkvascular.postpartum conditions, arthritis , bursitisSites of action:peripherally -- sites of inflammationsubcorticalsites
Analgesic Effects • Pain may arise from: Musculature, dental work , vascular , postpartum conditions, arthritis , bursitis • Sites of action: peripherally - sites of inflammation subcortical sites
NSAIDSProstaglandinsfactorspGF2pGE2BradrkininhistamineNerve ending ofpainblockprostaglandinsproductionSites ofaction:Painperipheral tissue
NSAIDs Prostaglandins pGE2 pGF2 Nerve ending of pain Pain Bradrkinin histamine factors + • block prostaglandins production • Sites of action: peripheral tissue
3.Anti-inflammatoryEffectsNSAIDs onlyinhibitthe Symptoms ofinflammationBut they neither arrest the progress of thedisease nor do they induce remission
3. Anti-inflammatory Effects • NSAIDs only inhibit the symptoms of inflammation • But they neither arrest the progress of the disease nor do they induce remission