HistoryIn1969thefirstassociationbetweenprostaglandin production and the actions ofaspirin-likedrugs.In1992newenzymewascloned&wascalled cyclooxygenase 2 (COX- 2) or PGH 2synthase2
History • In 1969 the first association between prostaglandin production and the actions of aspirin- like drugs • In 1992 new enzyme was cloned & was called cyclooxygenase 2 (COX- 2) or PGH 2 synthase 2
Common pharmacological effectsThese drugs show the same pharmacologicaleffects（解热）antipyretic effect（镇痛）analgesic effect（抗炎）anti-inflammatory effect
Common pharmacological effects These drugs show the same pharmacological effects • - antipyretic effect （解热） • - analgesic effect （镇痛） • - anti-inflammatory effect （抗炎）
1.Antipyretic Effects"normal"temperature: slightly affected"elevated"temperature:reducedThe higher temperature, the more potentMechanisms of Antipyretic ActionBlocks pyrogen-induced prostaglandinproduction in thermoregulatory center(CNS)
1. Antipyretic Effects • "normal" temperature: slightly affected • "elevated" temperature: reduced • The higher temperature, the more potent • Mechanisms of Antipyretic Action Blocks pyrogen-induced prostaglandin production in thermoregulatory center (CNS)
ProstaglandinsPyrogenpGE2NSAIDSthermoregulatorycenterAntipyretic MechanismBlockprostaglandinsset point ↑productionheat productionSites of action:Heat dissipation ↓Central Nervous SystemFever
NSAIDs Pyrogen Prostaglandins pGE2 thermoregulatory center heat production ↑ Heat dissipation ↓ set point ↑ Fever • Antipyretic Mechanism Block prostaglandins production • Sites of action: Central Nervous System
2.AnalgesicEffects. Effective to mild to moderate pain0.5g of aspirin is a weak or mildanalgesic that is effective in short.intermittent types of pain asencountered in neuralgia, myalgia (肉痛),toothache
2. Analgesic Effects • Effective to mild to moderate pain 0.5g of aspirin is a weak or mild analgesic that is effective in short, intermittent types of pain as encountered in neuralgia, myalgia (肌 肉痛), toothache