Antipyretic, analgesic and anti-inflammatorydrugsSichuan university
Antipyretic, analgesic and antiinflammatory drugs Sichuan university
Contents.OverviewHistory. Common pharmacologicaleffects阿斯匹林· Aspirin. Selective COS-2 inhibitor. Other Drugs
Contents • Overview • History • Common pharmacological effects • Aspirin 阿斯匹林 • Selective COS-2 inhibitor • Other Drugs
OverviewThis kind of drug is a group of chemically dissimilaragents that have antipyretic, analgesic and anti-inflammatory effects.The structure of this kind of drug differs from thatof steroidal anti-inflammatory drugs. Nonsteroidal anti-inflammatory drugs NSAIDs
Overview • This kind of drug is a group of chemically dissimilar agents that have antipyretic, analgesic and antiinflammatory effects. • The structure of this kind of drug differs from that of steroidal anti-inflammatory drugs. • Nonsteroidal anti-inflammatory drugs NSAIDs •
HistoryIn ancient Egypt & Greece, dried leaves of myrtle.thebarkofwillow&poplartreeIn England,active component from willow barkwasidentifiedassalicin（水杨苷）whichis（水杨酸盐）in1763metabolized to salicylate In Germany, salicylic acid（水杨酸）wassynthesized in 1860.（乙酰水杨酸）In1875,acetylsalicylicacidwassynthesized
History • In ancient Egypt & Greece, dried leaves of myrtle, the bark of willow & poplar tree • In England, active component from willow bark was identified as salicin (水杨苷）, which is metabolized to salicylate （水杨酸盐）in 1763. • In Germany, salicylic acid （水杨酸） was synthesized in 1860. • In 1875, acetylsalicylic acid （乙酰水杨酸） was synthesized
HistoryIn 1899,“Aspirin"acetylsalicylic acid)wasnamed; the "a" --- acetyl grouping and the"spirin" --- botanical genus spiraea, from whichsalicylates could be extracted. Now,more than3o million people consumeNSAIDs dailyand of these 40%of the patients aremore than 60 years of age.The consumption of NSAIDs is No. 1 among alldrugs
History • In 1899， “Aspirin“ （acetylsalicylic acid） was named; the "a" - acetyl grouping and the "spirin" - botanical genus spiraea, from which salicylates could be extracted. • Now, more than 30 million people consume NSAIDs daily and of these 40% of the patients are more than 60 years of age. • The consumption of NSAIDs is No. 1 among all drugs