(1)Antigenic determinants or epitopes Antigenic determinants or epitopes are the immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes (TCR/BCR)or to secreted antibodies
Antigenic determinants or epitopes are the immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes (TCR/BCR) or to secreted antibodies. (1) Antigenic determinants or epitopes
Structure of epitopes 1 Conformational epitope Nonsequential poly peptides or polysaccharide on the surface of the molecules Native conformation 2 iner epitope A sequential amino acid fragment, Linear determinant, Inside of the antigen molecule
1 Conformational epitope Nonsequential polypeptides or polysaccharide on the surface of the molecules, Native conformation, 2 liner epitope A sequential amino acid fragment, Linear determinant, Inside of the antigen molecule Structure of epitopes
( 3) hypervariable region vR (complimentarity lysozyme determining light chain heavy chain region, CDRE CDR DR light chain, heavy chain, formation of the variable domain variable domain Aa binding sIte light chain, heavy chain Framework constant domain constant domain region FR) maintaining the 3-dimensional configuration
(complimentarity determining region, CDR) : formation of the Ag binding site Framework region（ FR ) : maintaining the 3- dimensional configuration (3) hypervarible region (HVR)
CDR (complimentarity determining region. 131 CDR3 161 CDR1 CDR2 70 174 212 82 116 112 CL
(complimentarity determining region,) CDR
4. Ab-dependent Cell-mediated cytotoxicity, ADCC enhance NK killing Antibody binds antigens on Fc receptors on NK cells Cross-linking of Fc receptors signals the NK cell to kill Target cell dies by the surface of target cells recognize bound antibody the target cell apoptosis cyRIl (cD16) NK cell ctivated NK cell killing A人 Target cell
4. Ab-dependent Cell-mediated cytotoxicity, ADCC enhance NK killing