T celll T cell-mediated immunity Rui He ruihe@fudan.edu.cn Department of Immunology Shanghai Medical School Fudan University
T cell & Rui He ruihe@fudan.edu.cn Department of Immunology Shanghai Medical School Fudan University T cell-mediated immunity
Microbe Innate immunity Adaptive immunity I B lymphocytes Epithelial 薄 Antibodies barriers 真 ③ Phagocytes T lymphocytes Effector T cells 参 Complement NK cells Hours Days 6 Time after infection Abbas et al: Cellular and Molecular Immunology, Updated 6th Edition. opyright 2009 by Saunders, an imprint of Elsevier, Inc. All rights reserved
Types of adaptive immune responses Humoral Cell-mediated mmunity 督 督 Intracellular Extracellular Phagocytosed ymphocyt Helper B lymphocyte T lymphocyte T lymph Secreted antibody Effecto 督 x Transferred by」ar Serum Cells Cells es)(T lymphocytes),(T lymphocytes) Block Activate Kill infected infections and macrophages cells and Functions to kill eliminate extracellular phagocytosed:reservoirs microbes microbes of infection Abbas et al: Cellular and Molecular Immunology, Updated 6th Edition Copyright 2009 by Saunders, an imprint of Elsevier, Inc, All rights reserved
Types of adaptive immune responses
Agenda a Types of cell-mediated immune reactions a the differentiation of cd4tth cell subsets Q Effector mechanisms of cell-mediated immunity
Agenda ❑ Types of cell-mediated immune reactions ❑ The differentiation of CD4+Th cell subsets ❑ Effector mechanisms of cell-mediated immunity
Types of cell-mediated immune reactions 口CD4+ Th responses 口CD8+ CTL responses Delayed-type Hypersensitivity (DTH) T cell-dependent immune reactions that cause normal tissues injury NK cell mediated innate immunity, kill infected cell early
Types of cell-mediated immune reactions ❑ CD4+ Th responses ❑ CD8+ CTL responses Delayed-type Hypersensitivity (DTH) T cell-dependent immune reactions that cause normal tissues injury NK cell mediated innate immunity, kill infected cell early