Antigen-independent development of B cells o Bcell subsets and development Fetus liver: B1 B Bone marrow: HsC→proB→preB→imB→mB spleen: NFB FP FOB○ MZB⊙
B cell subsets and development Fetus liver：B1 B Bone Marrow： HSC proB preB imB mB spleen：NF B FP FO B MZ B Antigen-independent development of B cells
three major naive peripheral B-cell populations B cell MARGINAL ZONE FOLLICULAR B1 B CELLS B CELLS B CELLS IgM IgM CD21 IgM IgD CD21 CD23 Mac- CD5 CD1 T-independent responses T-dependent responses T-independent responses ?T-dependent responses T-independent responses Mucosal Immunity Immunity to blood borne Immune responses in mos B1a cells primarily of pathogens secondary lymphoid organs fetal liver origin Self-renewing? High-affinity IgG Self-renewing Immunol rev 2004: 197: 206
three major naive peripheral B-cell populations B cell Immunol Rev 2004; 197:206 High-affinity IgG
详 INSTITUTE FOR IMMUNOBIOLOGY B cell and B cell-mediated humoral immune response Part l Department of Immunology Fudan University Wei xu ph D 021-54237749 wx2362@hotmail.com
INSTITUTE FOR IMMUNOBIOLOGY B cell and B cell-mediated humoral immune response Part II Department of Immunology Fudan University Wei Xu, Ph.D 021-54237749 wx2362@hotmail.com
Overview of the humoral immune response against bacterial Humoral response CD4+Th Antigen B cell B cells interact with antigen Ab-secreti ng Antibody binds antigen and differentiate into plasma cells and facilitates its clearance antibody-secreting plasma cells from the body B cells plasma cells
Overview of the humoral immune response against bacterial B cells plasma cells
Significance of humoral immunity eliminate extracellular bacterium and toxin eliminate extracellular virus
Significance of humoral immunity eliminate extracellular bacterium and toxin eliminate extracellular virus