详 INSTITUTE FOR IMMUNOBIOLOGY B cell and B cell-mediated humoral immune response Department of Immunology Fudan University Wei xu. ph. D 021-54237749 wX2362@hotmail.com
INSTITUTE FOR IMMUNOBIOLOGY B cell and B cell-mediated humoral immune response Department of Immunology Fudan University Wei Xu, Ph.D 021-54237749 wx2362@hotmail.com
Adaptive immune response to pathogens Pathogens Humoral immunity cs Mature Secretes Bacteria Binds B cell Plasma cell viruses Fungi Cellular immunit Matures into active Foreign killer t cel proteins T cell CTL Virus-infected cell Killing reaction C ↓↓↓ Lymphokines Lysis
Adaptive immune response to pathogens
Overview of the humoral immune response against bacterial Humoral response CD4+Th Antigen B cell B cells interact with antigen Ab-secreti ng Antibody binds antigen and differentiate into plasma cells and facilitates its clearance antibody-secreting plasma cells from the body B cells plasma cells
Overview of the humoral immune response against bacterial B cells plasma cells
B lymphocyte 6 5%15%of peripheral lymphocytes g 25% lymph node and 45% splenic lymphocytes secret antibodies (ab) g act as antigen-presenting cell (APC)
B lymphocyte 5％～15％ of peripheral lymphocytes 25% lymph node and 45% splenic lymphocytes secret antibodies (Ab) act as antigen-presenting cell (APC)
B cells and humoral immune response 1. Surface molecules of b cell 2. B cell subsets 3.Bcel‖ development 4. Function and significance
B cells and humoral immune response 1. Surface molecules of B cell 2. B cell subsets 3. B cell development 4. Function and significance