Immune Responses to Tumors What is ADCC? ADCC: Antibody-Dependent Cell-Mediated Cytotoxicity Target Cell (Cancer Cell) Antibody Fc Receptor Tumor Lysis by ADCC TOTOXICITY Effector Cell (NK cell Monocyte) ADCC is a major mechanism for killing tumor cells by therapeutic antibodies
Immune Responses to Tumors
CONCEPT APCs are immunocytes that can uptake, process and present antigens to other lymphocytes
APCs are immunocytes that can uptake, process and present antigens to other lymphocytes. CONCEPT
Professional Apcs Dendritic Cells(DCs) Macrophages(Mo) B Lymphocytes
Dendritic Cells (DCs) Macrophages (M) B Lymphocytes Professional APCs
. Dendritic Cells(DCs) Ralph. M. Steinman. 1973
Ralph.M.Steinman, 1973 I. Dendritic Cells (DCs)
The invariant chain is cleaved to leave a peptide fragment, CLIP, bound to the MHC class li molecule CLIP (class Ill-associated invariant-chain peptide Invariant chain( )binds in li is cleaved initially to leave a Further cleavage leaves a short the groove of MHc class ll fragment bound to the class ll peptide fragment, CLIP, bound molecule molecule and to the membrane to the class ll molecule
The invariant chain is cleaved to leave a peptide fragment, CLIP, bound to the MHC class II molecule CLIP (class II-associated invariant-chain peptide)