AUTOIMMUNITY AND ATONMMUNE DTSEASE Bo Gao, Ph. D. email: gb1112@163.com Tel:54237379 DEPARTMENT OF IMMUNOLOGY INSTITUTE FOR IMMUNOBIOLOGY 2010-07-02 1
1 Bo Gao, Ph.D. DEPARTMENT OF IMMUNOLOGY INSTITUTE FOR IMMUNOBIOLOGY 2010-07-02 Email: gb1112@163.com Tel: 54237379
Contents: g Introduction c Organ-Specific Autoimmune Diseases e Systemic Autoimmune Diseases Mechanisms of induction g Treatment
2 Contents: Introduction Organ-Specific Autoimmune Diseases Systemic Autoimmune Diseases Mechanisms of Induction Treatment
ntroduction
3 Introduction
Autoimmunity origins y Horror autotoxicus Literally the horror of self- toxicity a term coined by the German immunologist paul Ehrlich(1854-1915) to describe the body's innate aversion to immunological self-destruction Paul Ehrlich. Nobel Prize in 1908 for demonstrating production of anti body
4 Autoimmunity Origins ➢Horror autotoxicus: Literally, the horror of selftoxicity. A term coined by the German immunologist Paul Ehrlich (1854-1915) to describe the body's innate aversion to immunological self-destruction. Paul Ehrlich , Nobel Prize in 1908 for demonstrating production of antibody
Clone selection hypothesis >Self-reactive lymphocyte were deleted during development Frank Burnet 1900--1990 E Nobel Prize 1960
5 Frank Burnet 1900--1990 Nobel Prize 1960 Clone selection hypothesis ➢Self-reactive lymphocyte were deleted during development