INSTITUTE FOR IMMUNOBIOLOGY Major Histocompatibility Complex MHC Department of Immunology Fudan University BO GAO. Ph D 021-54237154 gaobo@fudan.edu.cn
INSTITUTE FOR IMMUNOBIOLOGY Major Histocompatibility Complex MHC Department of Immunology Fudan University Bo GAO, Ph.D 021-54237154 gaobo@fudan.edu.cn
Major Histocompatibilty Complex, MHC 1. Discovery of MHC 2. MHC Genes 3. Binding of Peptides to MHC Molecules 4. MHC polymorphism 5. Function and significance
Major Histocompatibilty Complex, MHC 1. Discovery of MHC 2. MHC Genes 3. Binding of Peptides to MHC Molecules 4. MHC polymorphism 5. Function and significance
Autograft Isograft Within an < Identical Twins] indIidual Allograft Between speaes Xenograft Types of graft
Types of graft
MHC of mice 1940s Inbred mouse strains H-2d H-2b BALB/c C57BL/6 (George D Snell) Inbred mouse strains- all genes are identical
（George D. Snell) 1940s H-2 d H-2 b BALB/c C57BL/6 Inbred mouse strains MHC of mice Inbred mouse strains - all genes are identical
Genetic basis of transplant rejection Transplantation of skin between strains showed that rejection or acceptance was dependent upon the genetics of each strain ACCEPTED Skin from an inbred mouse grafted onto the same strain of mouse REJECTED Skin from an inbred mouse grafted onto a different strain of mouse
Skin from an inbred mouse grafted onto the same strain of mouse Skin from an inbred mouse grafted onto a different strain of mouse ACCEPTED REJECTED Genetic basis of transplant rejection Transplantation of skin between strains showed that rejection or acceptance was dependent upon the genetics of each strain