Chapter 10 Immunologic Tolerance General Features and Mechanisms T Lymphocyte tolerance o B lymphocyte tolerance Tolerance induced by Foreign Protein Antigens Homeostasis in the Immune System
Chapter 10 Immunologic Tolerance ⚫ General Features and Mechanisms ⚫ T Lymphocyte Tolerance ⚫ B Lymphocyte Tolerance ⚫ Tolerance induced by Foreign Protein Antigens ⚫ Homeostasis in the Immune System
What is Immunologic Tolerance? mmunologic Tolerance— an antigen induced specific unresponsiveness o Tolerogens 4 >Immunogens Failure ● Self-tolerance→→ Autoimmunity o Tolerance induced by foreign antigens
⚫ Immunologic Tolerance—— an antigen induced specific unresponsiveness ⚫ Tolerogens Immunogens ⚫ Self-tolerance →→ Autoimmunity ⚫ Tolerance induced by foreign antigens What is Immunologic Tolerance? Failure
General Features and mechanisms o Immunologically specific o A result of antigen recognition by specific lymphocytes
General Features and Mechanisms ⚫ Immunologically specific ⚫ A result of antigen recognition by specific lymphocytes
Studies of graft rejection in inbred mice Strain A Strain CBA Strain A cBA Neonate CBA CBA Balb/c Adult CBA Skin graft relection During lymphocyte maturation in the generative lymphoid organs, all Immunologically specific lymphocytes pass through a stage in. a result of the recognition of which encounter with Ag leads to antigens by specific lymphocytes tolerance
Neonate Adult Skin graft rejection + + _ Studies of graft rejection in inbred mice ⚫ Immunologically specific ⚫ a result of the recognition of antigens by specific lymphocytes During lymphocyte maturation in the generative lymphoid organs, all lymphocytes pass through a stage in which encounter with Ag leads to tolerance Strain A Strain A Strain A
General Features and mechanisms Immunologically specific ● Centra|to| erance: induced in generative lymphoid organs immature self-reactive lymphocyte The repertoire of mature lymphocytes cannot recognize ubiquitous or widely disseminated self antigens
General Features and Mechanisms ⚫ Immunologically specific ⚫ Central tolerance: induced in generative lymphoid organs immature self-reactive lymphocyte The repertoire of mature lymphocytes cannot recognize ubiquitous or widely disseminated self antigens The repertoire of mature lymphocytes cannot recognize ubiquitous or widely disseminated self antigens