B. Electrophysiological effects and classification of antiarrhythmic drugs u(2)Class II 口β adrenoceptor blockers propranolol普萘洛尔
(2) Class II adrenoceptor blockers propranolol 普萘洛尔 B. Electrophysiological effects and classification of antiarrhythmic drugs
Group Ill drugs prolong phase 3 repolarization without altering phase 0. Ph (3)Class Ill Prologation ofAPD Effe (K channel blocker prolongation of repolarization Outside amiodarone胺碘酮, sotalol索他洛尔 ca Ca K currents Action currents Sotalol, bretylium, and iodarone block potasslum channels
(3) Class III Prologation of APD (K+ channel blocker; prolongation of repolarization ) amiodarone 胺碘酮, sotalol 索他洛尔
Group Iv drugs slow phase 4 spontaneous depolarization and slow conduction in tissues dependent on calclum currents, such as AV node. 2 (4) Class IV Ca2+ channel ockers verapamil维拉帕米 Outside K currents Action potential Verapamil, diltiazem and nifedipine block open or inactivated calcium channels
(4) Class IV Ca2+ channel blockers verapamil 维拉帕米
B. Electrophysiological effects and classification of antiarrhythmic drugs D Class I( Na* channel blockers SV,V B IC SV.V* D Class II( B receptor blockers SV*V D Class Ill( prolongation of APD) SV,V D Class IV( Ca2*t channel blockers) Sv*, V primary action sites
Class I（Na+ channel blockers） IA SV, V* IB V IC SV, V* Class II（ receptor blockers） SV*, V Class III（prolongation of APD） SV, V Class IV（Ca2+ channel blockers） SV* , V B. Electrophysiological effects and classification of antiarrhythmic drugs * primary action sites
C Antiarrhythmic drugs n Class l drugs: Nat channel blockers d Class IA drugs Quinidine查尼丁 H2C--CH XH H CH-OH Hco
C. Antiarrhythmic drugs Class I drugs: Na+ channel blockers Class IA drugs Quinidine 奎尼丁