Growth Hormone Deficiency, GHD 生长激素缺乏症 Department of Endocrinology Children's hospital Fudan University
Growth Hormone Deficiency, GHD 生长激素缺乏症 Department of Endocrinology Children’s Hospital Fudan University
Introduction GHD is a disorder involves the pituitary gland Pituitary gland does not produce enough Gh Growth velocity is slower than normal GHD can occur at any age
• GHD is a disorder involves the pituitary gland • Pituitary gland does not produce enough GH • Growth velocity is slower than normal • GHD can occur at any age Introduction
Pathogenesis Growth hormone (GH) is a hormone that stimulates normal growth of bones and tissues GHD may result from disruption of the gh aXIs GHD may be isolated (isolated GHD)or associated with other pituitary deficiencies
• Growth hormone (GH) is a hormone that stimulates normal growth of bones and tissues • GHD may result from disruption of the GH axis • GHD may be isolated (isolated GHD) or associated with other pituitary deficiencies Pathogenesis
Pathogenesis GH is stimulated by gh-releasing hormone (GHRH) from the hypothalamus GH is stimulated by certain GH-releasing peptides ( grps) Somatostatin is secreted by the hypothalamus inhibits gh secretion
• GH is stimulated by GH-releasing hormone (GHRH) from the hypothalamus • GH is stimulated by certain GH-releasing peptides (GHRPs) • Somatostatin is secreted by the hypothalamus inhibits GH secretion Pathogenesis
GH Axis Hypothalamus GHRH (-) Thyroid gland-Anterior pituitary Gonads GH T E Liver IGF-1 Bone epiphysis
GH Axis Bone epiphysis Hypothalamus Anterior pituitary SS (-) GHRH (+) GH Liver IGF-1 (-) Gonads T E2 Thyroid gland T3 T4