Congenital Heart Diseases (cHD)先天性心脏病 复旦大学儿科医院
复旦大学儿科医院 Congenital Heart Diseases (CHD)先天性心脏病
Congenital Heart Diseases CHD先天性心脏病 General concept CHD occurs in approximately 6-8%o live births a In china. alone 250000 children with CHd are born each year a 30% of cases may die within first year of life The etiology remains unsolved Secondary prevention is the strategy at this stage
General concept ◼ CHD occurs in approximately 6-8‰ live births ◼ In China, alone 250000 children with CHD are born each year ◼ 30% of cases may die within first year of life ◼ The etiology remains unsolved ◼ Secondary prevention is the strategy at this stage Congenital Heart Diseases (CHD)先天性心脏病
Schematic Diagram of Cardiogenesis Bilaterally symmetrical cardiac progenitor cells form distinct regions of the heart The precardiac mesodermal cells give rise to a linear heart tube Forming a rightward loop Establishing the spatial orientation of the four-chambered mature heart
Schematic Diagram of Cardiogenesis ▪Bilaterally symmetrical cardiac progenitor cells form distinct regions of the heart ▪The precardiac mesodermal cells give rise to a linear heart tube ▪Forming a rightward loop ▪Establishing the spatial orientation of the four-chambered mature heart
Schematic Diagram of Cardiogenesis conotruncus AO 动脉干 RA主动脉肺动脉PA 动脉干 右心房 心室 动脉干 右心室 左心室 左心房LA → → 右心室 左心室 房 心房 右心室 左心室 心房 RV LV RV=right ventricle; LV=left ventricle; RA=right atrium Ao=aortic; LA-left atrium; PA-pulmonary artery
Schematic Diagram of Cardiogenesis RV LV LA PA conotruncus AO RV=right ventricle; LV=left ventricle; RA=right atrium Ao=aortic; LA=left atrium; PA=pulmonary artery RA
Fetal development One month 5th week 6th week 4星期 星期 期 8th week
Fetal development One month 5th week 6th week 8th week