呼吸链的组成-线粒体复合物Components of mtrespiration chain-mt complexIntermembranespaceHHInnermitochondrialmembraneNADFumarate1O2+2H+H.ONADH4HSuccinateMatrix17
呼吸链的组成-线粒体复合物 Components of mt respiration chain-mt complex 17
两条氧化呼吸链Twooxidativerespiratorychains1、NADH氧化呼吸链NADH oxidative respiratory chainNADH→复合体I→Q→复合体Ⅲ—CytC→复合体IV→O2NADH→complex I-Q→complex IIICyt c-→complex IV-→ O22、琥珀酸氧化呼吸链Succinicacidoxidativerespiratorychain琥珀酸→复合体Ⅱ→Q→复合体Ⅲ→Cytc→复合体IV→02Succinicacid→complexllQ→complexIll-Cytc→complexIV-→0218
两条氧化呼吸链 Two oxidative respiratory chains 1、 NADH氧化呼吸链 NADH oxidative respiratory chain NADH →复合体Ⅰ→Q →复合体Ⅲ→Cyt c →复合体Ⅳ→ O2 NADH →complex I→Q→complex III→Cyt c→complex IV→ O2 2、琥珀酸氧化呼吸链 Succinic acid oxidative respiratory chain 琥珀酸 →复合体Ⅱ →Q →复合体Ⅲ→Cyt c →复合体Ⅳ→O2 Succinic acid →complex II →Q →complex III→Cyt c →complex IV→ O2 18
氧化呼吸链的电子传递Electrontransferof oxidative respiratory chainCytc胞液侧eCytoplasm00000YY0线粒体内膜eMtInnermembraneeIVⅡI00基质侧延胡索酸NADH+H+H20MtMatrixFumaric acid1/202+2H+NAD+琥珀酸Succinic acid19
胞液侧 Cytoplasm 基质侧 Mt Matrix 线粒体内膜 Mt Inner membrane 氧化呼吸链的电子传递 Electron transfer of oxidative respiratory chain Q 1/2O2+2H+ H2O Ⅲ Ⅰ Ⅱ Ⅳ 延胡索酸 Fumaric acid 琥珀酸 Succinic acid e - Cytc e - e - e - e - NADH+H+ NAD+ 19
线粒体工作原理：三羧酸循环与氧化磷酸化偶联Mitochondrial ElectronTransportChain1IVIIIComplex:I2H2H+2x2H0o1ND1OUTInnermitochondrialmemhrune1399.ATP1351OuinonvilepoolsynthaseIN1A102FunarateHoSuccinatedehydrogenaseO3.6.1.366134fomeCytochromebe1complex3.6.1.15HHHNAD'NADHdehydrogenaseATPADPNADHKrebsPeter S.Rabinwitch after Mandavilli et al, Mutation Research509 (2002) 127-151Cycle
Krebs Cycle e - e - e - e - H+H+ H+H+ Cyt C e - e - H+H+ O2 H+H+H2O ADP ATP Cyt C e - O2 Q H+`H+ NADH NAD+ H+ H+ H+ H+H+ H+ Cyt C H+` e - e - e - IN OUT Peter S. Rabinwitch after Mandavilli et al, Mutation Research 509 (2002) 127–151 线粒体工作原理 :三羧酸循环与氧化磷酸化偶联 Mitochondrial Electron Transport Chain 2OH- OH-
线粒体内质子梯度的形成Formation of proton gradient电子传递驱动质子外流形成电化学梯度ohH高pH低[H+]（基质）低pH高[H+]（膜间腔）2
线粒体内质子梯度的形成 Formation of proton gradient 21