Hemolytic anemias Intrinsic abnormalities of the red blood cell <Structural defects Hereditary spherocytosis Hemolytic elliptocytosis Paroxy knocytosis Enzymatic defects(nonspherocytic hemolytic anemias) Enzymes of glycolytic pathway--pyruvate kinase, hexokinase, and others Enzymes of the pentose phosphate pathway and glutathione complex Defects in synthesis of hemoglobin Hb s C, D,E etc alone and in com bination Thalassemia (國)复旦大学上海医学院儿科学系
Hemolytic anemias Intrinsic abnormalities of the red blood cell “Structural” defects Hereditary spherocytosis Hemolytic elliptocytosis Paroxyknocytosis Enzymatic defects (nonspherocytic hemolytic anemias) Enzymes of glycolytic pathway---pyruvate kinase, hexokinase, and others Enzymes of the pentose phosphate pathway and glutathione complex Defects in synthesis of hemoglobin Hb S, C, D, E, etc, alone and in combination Thalassemia
Extrinsic(extracellular) abnormalites Immunologic disorders Passively acquired antibodies(hemolytic disease of the newborn) Rh isoimmunization A or B isoimmunization Other blood group families Active antibody formation Idiopathic autoimmune hemolytic anemia; cold agglutinin diseases Symptomatic---lupus, lymphoma Drug---induced (國)复旦大学上海医学院儿科学系
Extrinsic (extracellular) abnormalites Immunologic disorders Passively acquired antibodies (hemolytic disease of the nemborn) Rh isoimmunzation A or B isoimmunization Other blood group families Active antibody formation Idiopathic autoimmune hemolytic anemia; cold agglutinin diseases Symptomatic---lupus, lymphoma Drug---induced
Nonimmunologic disorders Toxic from drugs, chemicals Infections---malarial. clostridial 回复旦大学上海医学院儿科学系
Nonimmunologic disorders Toxic from drugs, chemicals Infections---malarial, clostridial
io. do P|ate155-13 Pate155-14 155-13 Normal red cell morphology 155-14 Microcytes in IDA a00 155-15 Megalocytes in Pla 15 pernicious anemia
155-13 Normal red cell morphology 155-14 Microcytes in IDA 155-15 Megalocytes in pernicious anemia
Nutritional anemias Iron deficiency anemia v Megaloblastic anemia 回复旦大学上海医学院儿科学系
Nutritional Anemias Iron deficiency anemia Megaloblastic anemia