Lower limit of normal hemoglobin values at various ages neonate Hb<1459/L Hb<90g儿L 4~6m Hb 100 a/L 6m w by Hb< 110 g/L 6y~14yHb<1209/L Degree of anemia Mild Moderate Severe Extremely severe ~90q儿L~60q/L ~30q/L <309/L Neonate w120 g/L M90 g/L 60 g/L <60q/L 回复旦大学上海医学院儿科学系
Lower limit of normal hemoglobin values at various ages neonate Hb 145 g/L 1 ~ 4m Hb 90 g/L 4 ~ 6m Hb 100 g/L 6m ~ 6y Hb 110 g/L 6y ~ 14y Hb 120 g/L Degree of anemia Mild Moderate Severe Extremely severe ~90 g/L ~60 g/L ~30 g/L 30 g/L Neonate ~120 g/L ~90 g/L ~60 g/L 60 g/L
Y Anemia is not a specific entity but an indication of an underlying pathologic process or disease v Two useful classification of anemias Physiologic(erythrokinetic) classification 1. those resulting primarily from decreased production of red blood cells or hemoglobin 2. those in which increased destruction or loss of red blood cells Morphologic classification the red blood cells being characterized by their mean corpuscular volume(MCV) as microcytic(MCV<75fD) macrocytic(MCV> 100f ), or normocytic (75-100fl) 回复旦大学上海医学院儿科学系
✓ Anemia is not a specific entity but an indication of an underlying pathologic process or disease ✓ Two useful classification of anemias Physiologic (erythrokinetic) classification 1. those resulting primarily from decreased production of red blood cells or hemoglobin 2. those in which increased destruction or loss of red blood cells Morphologic classification the red blood cells being characterized by their mean corpuscular volume (MCV) as microcytic (MCV < 75fl), macrocytic (MCV > 100fl), or normocytic (75-100fl)
Classification of the Anemias Anemias resulting primary from inadequate production of red blood cells or hemoglobin Hemolytic anemias EXtrinsic(extracellular) abnormalities Nonimmunologic disorders 回复旦大学上海医学院儿科学系
Classification of the Anemias • Anemias resulting primary from inadequate production of red blood cells or hemoglobin • Hemolytic anemias • Extrinsic (extracelllular) abnormalities • Nonimmunologic disorders
Anemias resulting primary from inadequate production of red blood cells or hemoglobin Decreased numbers of red blood cell precursors in the marrow" Pure red blood celpanemia Congenital pure red blood cell anemia Acquired pure red blood cell anemias(e. g. TEC) Inadequate production despite normal numbers of red blood cell precursors Anemia of infection, inflammation, and cancer Anemia of chronic renal disease Congenital dyserythropoietic anemias 回复旦大学上海医学院儿科学系
Anemias resulting primary from inadequate production of red blood cells or hemoglobin Decreased numbers of red blood cell precursors in the marrow “Pure red blood cell” anemia Congenital pure red blood cell anemia Acquired pure red blood cell anemias (e.g. TEC) Inadequate production despite normal numbers of red blood cell precursors Anemia of infection, inflammation, and cancer Anemia of chronic renal disease Congenital dyserythropoietic anemias
Anemias resulting primary from inadequate production of red blood cells or hemoglobin Deficiency of specific factors Megaloblastic anemias Folic acid deficiency or malabsorption Vitamin B12 deficiency, malabsorption, or transport Orotic aciduria Microcytic anemias Iron deficiency Pyridoxine-responsive and X-linked hypochromic anemias Lead poisoning Copper deficiency Thalassemia trait (國)复旦大学上海医学院儿科学系
Anemias resulting primary from inadequate production of red blood cells or hemoglobin Deficiency of specific factors Megaloblastic anemias Folic acid deficiency or malabsorption Vitamin B12 deficiency, malabsorption, or transport Orotic aciduria Microcytic anemias Iron deficiency Pyridoxine-responsive and X-linked hypochromic anemias Lead poisoning Copper deficiency Thalassemia trait