Neonatal Neurological Diseases 陈超 Childrens Hospital, Fudan University
Neonatal Neurological Diseases 陈 超 Children’s Hospital，Fudan University
Neonatal Hypoxic-Ischemic Encephalopathy 新生儿缺氧缺血性脑病 (HIE)
Neonatal Hypoxic-Ischemic Encephalopathy 新生儿缺氧缺血性脑病 （HIE）
l。 Causes Hypoxia Perinatal asphyxia, apnea, respiratory failure, right to left shunt schemia Heart arrest, Heart failure, Shock
Hypoxia Perinatal asphyxia, apnea, respiratory failure, right to left shunt Ischemia Heart arrest，Heart failure, Shock 1. Causes
Onset of he Timing of Insults Percentage Antepartum 20 Intrapartum 35 Antepartum t antepartum 35 Postnatal 10
Onset of HIE Timing of Insults Percentage Antepartum 20 Intrapartum 35 Antepartum antepartum 35 Postnatal 10
Pathogenesis 1. Cerebral hemodynamic alteration 脑血流重分布 Initial changes: redistribution of circulation ( diving reflex)→> cerebral blood flow↑ Continue insult: loss of vascular autoregulation, systemic hypotension, cerebral blood flow cerebral ischemia
1. Cerebral hemodynamic alteration： 脑血流重分布 Initial changes：redistribution of circulation (diving reflex) → cerebral blood flow↑ Continue insult：loss of vascular autoregulation, systemic hypotension, cerebral blood flow↓ cerebral ischemia Pathogenesis