The lifecycle of HBV HBsAg Spherical Filamentous Pre-s truncation HBsAg ENTRY Mature HBV vinon GOLGI Nuclear ranspo ER Pre-S1 mRNA HBSAg nucleocapsid Pre-S2/S mRNA M. S Viral integration Precore mRNA Core RC-DNA Veev RNA polymerase Nucleu CCCDNA Intracellular Recycling Pathway Journal of Hepatology 2011
The lifecycle of HBV Journal of Hepatology 2011
Three antigen-antibody system(1) HBSAg-- anti-HBs system HBSAg The hallmark for the diagnosis of hbv infection Quantitative serum HBSAg has a new potential role in the prediction of virological response to antiviral therapy, Anti-HBs antibody a protective antibody HBSAg loss and anti-HBs development are considered to have resolved hepatitis b 12
Three antigen-antibody system(1) • HBsAg-- anti-HBs system: HBsAg The hallmark for the diagnosis of HBV infection Quantitative serum HBsAg has a new potential role in the prediction of virological response to antiviral therapy, Anti-HBs antibody A protective antibody HBsAg loss and anti-HBs development are considered to have resolved hepatitis B 12
Three antigen-antibody system(2) ● HBCAg-antⅰ- H Bc system HBCAg can be found in the nuclei of liver cells no free hbcag in serum HBCAg is the marker of replication of hbv Anti-HBc IgM is a marker of acute infection and acute attack of chronic infection of hbv Anti-HBc IgG is the marker of past infection 13
Three antigen-antibody system(2) • HBcAg--anti-HBc system HBcAg can be found in the nuclei of liver cells, no free HBcAg in serum HBcAg is the marker of replication of HBV Anti-HBc IgM is a marker of acute infection and acute attack of chronic infection of HBV. Anti-HBc IgG is the marker of past infection, 13
Three antigen-antibody system ( 3) HBeAg-anti-HBe system HBeag is a soluble antigen HBeag is a reliable indicator of active replication of HBv Anti-HBe is a marker of reduced infectivity HBeAg seroconversion endpoint 14
Three antigen-antibody system(3) • HBeAg—anti-HBe system HBeAg is a soluble antigen HBeAg is a reliable indicator of active replication of HBV Anti-HBe is a marker of reduced infectivity • HBeAg seroconversion: endpoint 14
Hepatitis C virus(HCv HCV genome is a single stranded positive-sense rna and 9. 4kb long HCV genome may be divided into 6 genotypes The most common genotypes are 1a and 1b HCV genotype is a major determinant of the response to interferon-a-based therapies Antigen-antibody system anti-HCV is the indicator of infection HCV-RNA is the direct evidence of infectivity 15
Hepatitis C virus (HCV) • HCV genome is a single stranded positive-sense RNA and 9.4kb long • HCV genome may be divided into 6 genotypes • The most common genotypes are 1a and 1b • HCV genotype is a major determinant of the response to interferon-α–based therapies. • Antigen-antibody system anti-HCV is the indicator of infection • HCV-RNA is the direct evidence of infectivity 15