Hepatitis b virus HBV is a kind of hepadnavirus Three particles in serum two types of non-infectious particles spherical particles and filamentous forms, composed of Surface antigen(HBsag) Dane particle: infectious particles °10 genotypes
Hepatitis B virus • HBV is a kind of hepadnavirus • Three particles in serum: two types of non-infectious particles: spherical particles and filamentous forms, composed of Surface antigen (HBsAg) Dane particle: infectious particles • 10 genotypes 6
HBV genome and open reading frames Hepatitis b virion genome is a small circular, partially double stranded dNA with 3. 2kb long Four open reading frames(ORF) coded on the minus strand: C, S, X, and p region S regions: encode pre-s1, pre-S2 and HBSAg C region included pre-C and c gene, encode HBeAg and HBCAg X region encodes HBxAg P region encodes dNA polymerase
HBV genome and open reading frames Hepatitis B virion genome is a small circular, partially double stranded DNA with 3.2kb long. Four open reading frames (ORF) coded on the minus strand: C, S, X, and P region: S regions: encode pre-s1, pre-s2 and HBsAg. C region included pre-C and C gene, encode HBeAg and HBcAg X region encodes HBxAg P region encodes DNA polymerase
Hepatitis B Virus Dane particle and genome HBV HBsA HBCA DNA Polymerase Partially double-stranded DNA HBeAg( circulating form OOOOOO Partially double-stranded circular dna virus A member of the Hepadnaviridae
8 Hepatitis B Virus Dane Particle and Genome HBsAg HBcAg Partially double-stranded DNA HBeAg (circulating form) DNA Polymerase Partially double-stranded circular DNA virus A member of the Hepadnaviridae HBV
Hepatitis B Genome HBSA 13 Polymerase erase Partially double stranded HBeA form Partially double-stranded circular dna virus A member of the Hepadnaviridae 1816 Chen WN, Oon CJ. FEBS Letters 453 237-242(1999) HBcAg Hunt, et al., Hepatology, 31, 5, 1037-1044(2000) HBeA g Lee WM. The New England Journal of Medicine 337,24,1733-1745(1997)
9 Hepatitis B Genome HBcAg, HBeAg Polymerase HBsAg • Partially double-stranded circular DNA virus • A member of the Hepadnaviridae Chen WN, Oon CJ. FEBS Letters 453 237-242 (1999) Hunt, et al., Hepatology, 31, 5, 1037-1044 (2000) Lee WM. The New England Journal of Medicine, 337, 24, 1733-1745 (1997) HBsAg HBcAg Polymerase Partially double stranded DNA HBeAg circulating form
Three particles in serum a8 10 1010 1013
Three particles in serum