FEVER CHEN SHU nfectious Disease Division Huashan Hospital, Fudan University
FEVER CHEN SHU Infectious Disease Division Huashan Hospital, Fudan University
Fever o Normal body temperature 口37°C( set point D Circadian variation <10C: 363-37.20C 口 rectal t0.40C> oral t0.40C>aⅫ illary T ● Definition of fever D An elevation of core body temperature above the normal range
Fever ⚫ Normal body temperature: 37oC (set point) Circadian variation <1o C ：36.3 - 37.2oC rectal T 0.4oC > oral T 0. 4oC > axillary T ⚫ Definition of fever: An elevation of core body temperature above the normal range
Fever(with pyrogens) Pyrogens数热原 Elevated set-point Maintaining an abnormally elevated Temperature BMR(basal metabolic rate) increases BMR个10% =T个0.6°C T个= Elevated set-point
Fever(with pyrogens) Pyrogens 致热原 Elevated set-point Maintaining an abnormally elevated Temperature BMR(basal metabolic rate) increases T = Elevated set-point BMR 10% = T 0.6oC
PATHOGENESIS OF FEVER Antigens HYPOTHALAMUS Antigen antibody lymphocyte complex Bacteria and Prostaglandin E bacterial products m Endogenous Increase in body pyrogens temperature -(interleukin 1) set point (Tumor necrosis factor) Viruses (Interferon a) Heat generation Mononuclear Heat conservation phagocyte Crystals (eg. urate) Fever
PATHOGENESIS OF FEVER
ExP Macrophage EnP e hypothalamus lymphocyte Heat lossy Fever Set point↑ Heat production个
Set point hypothalamus Heat loss Heat production Fever ExP Macrophage lymphocyte EnP