Viral hepatitis Jiming Zhang(张继明),MD Professor of medicine Department of Infectious Diseases Huashan Hospital, Fudan University
Viral Hepatitis Jiming Zhang (张继明）, M.D. Professor of Medicine Department of Infectious Diseases Huashan Hospital, Fudan University 1
张继明教授简介 复旦大学附属华山医院主任医师,教授,博士研究生导师 教育部与卫生部医学分子病毒学重点实验室双聘教授 华山医院肝病研究室主任,感染病科副主任 华山医院药物临床试验机构肝病专业组组长 2011年度“复旦大学优秀研究生导师” 上海市病毒学分会主任委员 上海市肝病学分会委员、内科学分会委员 研究方向为慢性乙肝的发病机制、乙型肝炎病毒耐药变异等 目前承担国家级课题7项 E-mai l: jmzhang@fudan edu cn
复旦大学附属华山医院主任医师，教授，博士研究生导师 教育部与卫生部医学分子病毒学重点实验室双聘教授 华山医院肝病研究室主任，感染病科副主任 华山医院药物临床试验机构肝病专业组组长 2011年度“复旦大学优秀研究生导师” 上海市病毒学分会主任委员 上海市肝病学分会委员、内科学分会委员 研究方向为慢性乙肝的发病机制、乙型肝炎病毒耐药变异等 目前承担国家级课题7项 E-mail: jmzhang@fudan.edu.cn 张继明教授简介
Definition Viral hepatitis is a group systemic infection affecting the liver predominantly caused by 5 kinds of viruses at least Five hepatotropic hepatitis viruses are responsible for the vast majority of hepatitis cases(classical Hepatitis a virus(HAv) Hepatitis B virus(HBv) Hepatitis C virus(HCv Hepatitis d or delta virus(hDv Hepatitis E virus(HEv)
Definition • Viral hepatitis is a group systemic infection affecting the liver predominantly caused by 5 kinds of viruses at least • Five hepatotropic hepatitis viruses are responsible for the vast majority of hepatitis cases(classical) : Hepatitis A virus (HAV) Hepatitis B virus (HBV) Hepatitis C virus (HCV) Hepatitis D or delta virus (HDV) Hepatitis E virus (HEV) 3
The pathogen
The pathogen 4
Hepatitis a virus a positive-stranded rna genome approximately 7.5 kb long At least 4 different hav genotypes(l, ll, Ill, and Vil) Only one antigen-antibody system °Ant-HA∨ Igm is diagnostic evidence of recent infection Igg is protective antibody
Hepatitis A Virus • A positive-stranded RNA genome approximately 7.5 kb long • At least 4 different HAV genotypes ( I, II, III, and VII) • Only one antigen-antibody system. • Anti-HAV IgM is diagnostic evidence of recent infection • IgG is protective antibody 5