Clinical Proteomics This area of proteomics focuses on accelerating drug development for diseases through the systematic identification of potential drug targets I How could this be accomplished? a Hopefully, we will have more specific information instead of raw genes, that will make those complex differential equations much simpler in the coming years 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 21 • Clinical Proteomics Clinical Proteomics This area of proteomics focuses on accelerating This area of proteomics focuses on accelerating drug development for diseases through the drug development for diseases through the systematic identification of potential drug targets. systematic identification of potential drug targets. How could this be accomplished? How could this be accomplished? Hopefully, we will have more specific information, Hopefully, we will have more specific information, instead of raw genes, that will make those complex instead of raw genes, that will make those complex differential equations much simpler in the coming differential equations much simpler in the coming years
Applications of Proteomics a Mining: identification of proteins(catalog the proteins) a Protein-expression profile: identification of proteins in a particular state of the organism I Protein-network mapping: protein interactions in living systems a Mapping of protein modifications: how and where proteins are modified 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 22 Applications of Proteomics Applications of Proteomics Mining: identification of proteins (catalog Mining: identification of proteins (catalog the proteins) the proteins) Protein Protein-expression profile: identification of expression profile: identification of proteins in a particular state of the proteins in a particular state of the organism organism Protein Protein-network mapping: protein network mapping: protein interactions in living systems interactions in living systems Mapping of protein modifications: how and Mapping of protein modifications: how and where proteins are modified. where proteins are modified
Proteomics and Systems Biology The identification characterization and quantification of all proteins involved in a particular pathway, organelle, cell, tissue, organ or organism and comprehensive data about that system. Crate that can be studied in concert to provide acct → Systems Biology http://www.inproteomics.com/prodef.html 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 23 Proteomics and Systems Biology Proteomics and Systems Biology “The identification, characterization and The identification, characterization and quantification of all proteins involved in a particular quantification of all proteins involved in a particular pathway, organelle, cell, tissue, organ or organism pathway, organelle, cell, tissue, organ or organism that can be studied in concert to provide accurate that can be studied in concert to provide accurate and comprehensive data about that system. and comprehensive data about that system.” Systems Biology Systems Biology http://www. http://www.inproteomics inproteomics.com/prodef.html
Genomics global Targeted Functional Transcriptomics genomIcs global Targeted Proteomics global Targeted Metabolomics global Targeted Interactomics System Biology 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 24 Genomics Functional genomics global Targeted Transcriptomics Proteomics global Targeted global Targeted Metabolomics global Targeted Interactomics System Biology
Systems biology is an approach to studying complex biological systems made possible through technological breakthroughs such as the human genome project..systems biology simultaneously studies the complex interaction of many levels of biological information to understand how they work together http://www.systemsbiologyorg 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 25 “Systems biology is an approach to studying complex biological systems made possible through technological breakthroughs such as the human genome project. …systems biology simultaneously studies the complex interaction of many levels of biological information to understand how they work together.” http://www.systems biology.org/