Part v Structural Proteomics 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 1 Part VI. Structural Proteomics
Structural proteomics Structural proteomics has the goal of obtaining useful, three-dimensional models of all proteins by a combina- tion of experimental structure determination and comparative model building 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 2 Structural proteomics Structural proteomics Structural proteomics has the goal of obtaining useful, three-dimensional models of all proteins by a combination of experimental structure determination and comparative model building. Structural proteomics has the goal of obtaining useful, three-dimensional models of all proteins by a combination of experimental structure determination and comparative model building
Computation Cellular Developmental Morphogenesis and Developm ent Signal Transduction P athways Bio chemical Path叫ays Predicting Catalysis, Molecular/ Structures of Mult Experiments redidting Effects of m RNAc. and othe Prediding Three-Dimensional Predicting Functions Biome locule Structures ofp rote ins and RNAs Predictng Protein Simulating and Understanding Gene Expression Networks Reconstructing Phylogeny Genome Large- scale \Genes and Gene Structures Homology, and Comparitive equenc Assem bled Genomes Sequence variation of The experimental (left and computational (right) hierarchies will increasingly become codependent as the research community models greater biological complexity 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 3 The experimental (left) and computational (right) hierarchies will increasingly become codependent as the research community models greater biological complexity. The experimental (left) and computational (right) hierarchies will increasingly become codependent as the research community models greater biological complexity
Genome Sequencing Projects Cell Microorganism Target s Selection PDB Database 0 0 HT Crystallography and NMr Functional Studies Structural genomics Drug Development Metabolic Pathways Structure+ Function ew Family mem bers Characterization New Folds Homology Modeling Global structural genomics efforts will be major players in Completing the protein family and fold landscape 0/27/2005 haoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 4 Global structural genomics efforts will be major players in Completing the protein family and fold landscape. Global structural genomics efforts will be major players in Completing the protein family and fold landscape
Table 1 List of pilot projects in structural genomics Pilot project organizers Organism SBurley, A Sali, J. Sussman S cerevisiae A. Edwards M. thermoautotrophicum D. Eisenberg, T. Terwilliger P aerophilum S,-H. Kim M. janaschii G. Montelione, S Anderson Metazoa Moult H influenzae S Yokoyama T Thermophilus, HB8 These projects were described at the meeting. Each project gen erally involves several independent laboratories. Only speakers at the meeting are listed in the first column Their addresses can be foundathttp://lion.cabm.rutgersedw/bioinformatics_meeting 0/27/2005 Chaoqun Wu, Fudan University
10/27/2005 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 5