NADH+H+ 0 FADH2 Fe Succinate dehydrogenase -50 NADH-O reductase Ubiquinone(Q) complex Cytochrome c reductase Fe complex Cytochrome c 03 BAlea -100 Cytochrome c oxidase complex -150 200 02 H,0
Complex I -NADH Dehydrogenase Complex (NADH-CoQ Reductase Complex) composed of 46 polypeptides (largest protein in the membrane) passes electrons to UQ contains FMN and seven iron-sulfur centers which mediate one-electron transfers
Complex I -NADH Dehydrogenase Complex (NADH-CoQ Reductase Complex) - composed of 46 polypeptides (largest protein in the membrane) - passes electrons to UQ - contains FMN and seven iron-sulfur centers which mediate one-electron transfers
Two Iron-Sulfur Centers Protein Fe Protein
Two Iron-Sulfur Centers
Structure and Oxidation States of Coenzyme Q Coenzyme Q HC- CH. A lipid soluble (Ubiquinone,UQ) CH2一CH=C一CH2 mobile electron HC-01 carrier that accepts or ●A donates CHa electrons one at CH a time Ubisemiquinone HC-O CH HC-O CH,-CH= Dihydroubiquinone
Structure and Oxidation States of Coenzyme Q A lipid soluble mobile electron carrier that accepts or donates electrons one at a time
Transfer of Electrons Through Complex I of the Mitochondrial Electron Transport Chain Matrix NAD* NADH+⊙ -MN FMN 2日 2 Fe-S Centers 2 Ht uQ 2 Fe-S Centers Intermembrane 2 2日 space
Transfer of Electrons Through Complex I of the Mitochondrial Electron Transport Chain