2012-2013 Final term examination for Cellular Biochemistry Name student ID number Choose one correct answer for each questions(1 point per question,100 choice questions,total 100 points) 1.The difference between rough endoplasmic reticulum and smooth endoplasmic reticulum is that rough endoplasmic reticulum A.does not contain ribosomes B.contains ribosomes C.does not contain liposomes D.contains liposomes E.None of the above 2.Ribozyme is Aribosomal proteins B.catalytic RNA C.enzyme for the synthesis of ribosome D.lipids E None of the above 3 What cell organelle is pictured below? A Nucleus B.Golgi complex C.mitochondrion D.centriole E.lysosome 4.Which of the followings is not a trait of stem cell? A.asymmetry division B.self-renewal C.plasticity D.self-maintenance E metastasis 5.The main function of ribosome is to A.neutralize poisons B.produce DNA C.destroy old organells D.synthesize proteins E.none ofabove 6.Proteins are made oflong chains of A.lipids B. C.enzymes DNucleotide E.carbohydrate 7.The inner folded membranes of mitochondria are called A.Cristae. B.Thvlakoids C.Golgi body D.Endoplasmic reticulum E.SER 8.The cell membrane consists mainly of A.water and carbondioxide B.cellulose and pectin C.phospholipids and proteins D.actin and myosin E none of above
2012-2013 Final term examination for Cellular Biochemistry Name student ID number: Choose one correct answer for each questions (1 point per question, 100 choice questions, total 100 points ) 1. The difference between rough endoplasmic reticulum and smooth endoplasmic reticulum is that rough endoplasmic reticulum A．does not contain ribosomes B．contains ribosomes C．does not contain liposomes D．contains liposomes E．None of the above 2. Ribozyme is A ribosomal proteins B.catalytic RNA C.enzyme for the synthesis of ribosome D.lipids E.None of the above 3. What cell organelle is pictured below? A. Nucleus B.Golgi complex C. mitochondrion D.centriole E. lysosome 4. Which of the followings is not a trait of stem cell? A. asymmetry division B. self-renewal C. plasticity D. self-maintenance E. metastasis 5. The main function of ribosome is to A. neutralize poisons B. produce DNA C. destroy old organells D. synthesize proteins E. none of above 6．Proteins are made of long chains of A. lipids B. amino acids C. enzymes D Nucleotide E.carbohydrate 7. The inner folded membranes of mitochondria are called A.Cristae. B.Thylakoids C.Golgi body D. Endoplasmic reticulum E.SER 8. The cell membrane consists mainly of A．water and carbondioxide B. cellulose and pectin C.phospholipids and proteins D.actin and myosin E none of above
9.The core proteins in nucleosome are A H2A H2R H3 H4 R HIA HIR H3 HA C.HIA,H2A,H3,H4 D.H1,H2,H3,H4 E.H2A,H2B,H1,H2 10.How many nucleotide bases are needed to code for one amino acid? A.One B.two C.three D.four E.five 11.The microtubulesserve as amajor component of A.vacuoles B.cilia and flagella C.DNA D.the mitochondria E.None of the above 12 How do eukarvotic cells differ from prokaryotic cells? A.Eukaryotic cels are larger than prokaryo cells C.Eukaryotic cells have their DNA packaged in a nucleus D.All of the above are correct about eukaryotic cells E.None of the above 13.The cell boundary is ealled the A.Cytoplasm B.nuclear membrane C.cell membrane D.endoplasmic reticulum E.None of the above 14 The function of mitochondria is to B.provide a great deal of cellular energy C move the cel D encode genetic information ENone of the above 15.The following graph shows the effect of 4 mutagens on human skin and blood cells grown in a laboratory. One conclusion that might be drawn from this information is that Key ☐skin cell ☐blood cell A.human cells are equally affected by mutagens. B.mutagens affect cells in different ways. C.nitrous oxide (NO)equally affects skin and blood cells. D Nico tine isequally harmful to all human cells. E.blood cells are more sensitive to mutagens than skincel 16.Active transport A uses cell membrane proteins
9. The core proteins in nucleosome are A. H2A, H2B, H3, H4. B. H1A, H1B, H3, H4. C. H1A, H2A, H3, H4. D. H1, H2, H3, H4. E. H2A, H2B, H1, H2. 10. How many nucleotide bases are needed to code for one amino acid? A. One B.two C.three D. four E.five 11. The microtubules serve as a major component of A. vacuoles B. cilia and flagella C. DNA D. the mitochondria E. None of the above 12. How do eukaryotic cells differ from prokaryotic cells? A．Eukaryotic cells are larger than prokaryotic cells B．Eukaryotic cells have cell components called organelles C．Eukaryotic cells have their DNA packaged in a nucleus D．All of the above are correct about eukaryotic cells E．None of the above 13．The cell boundary is called the A.Cytoplasm B.nuclear membrane C. cell membrane D.endoplasmic reticulum E. None of the above 14. The function of mitochondria is to A package cell products for cell export B. provide a great deal of cellular energy C move the cell D encode genetic information E None of the above 15. The following graph shows the effect of 4 mutagens on human skin and blood cells grown in a laboratory. One conclusion that might be drawn from this information is that A. human cells are equally affected by mutagens. B. mutagens affect cells in different ways. C. nitrous oxide（NO）equally affects skin and blood cells. D. Nicotine is equally harmful to all human cells. E. blood cells are more sensitive to mutagens than skin cells 16. Active transport A.uses cell membrane proteins
B.requires ATP chemical energy C.an transport froma region of toa region of high D.all of the above are true.Enone of the above 17.Human red blood cells are the ideal materials to study the cell membrane structures because A.Red blood cells can be easily identified by their color B.Red blood cells are available in large number C.Red blood cells have no nucleus and organelles D.Both BandC E.A+B 18.The muscle contraction requires the action of which molecular motor? A.Kinesin B.Myosin.C.Dynein D.Tubulin E.actin 19.Which of the following about apoptosis is not true? A.Isa sort of cellular self-destruction that can take place in normal tissues B.Is accompanied by random DNA degradation C.Is characterized by nuclear fragmentation and cellular breakdown into vesicles. D.Differs from necrosis because necrosis occurs when cell is injured. E.all ofabove 20.Necrosis A.May be mediated by FAS signal pathway. B.Characterized by DNA degraded into about 200bp fragment. C.Is a genetically controlled process D.Occurs when cel is injured E.None of the above 21.In an experiment to test their new drug on humans,two scientists planned to give volunteers one of two drugs Drug A- experimental drug Which of thes ould MOS of the scientists who developed the epcrimctaldnug A.Introduce a third drug into the experiment B.Decrease the number of experimenters from two to one C.Have a third researcher label and distribute the samples D.Replacea portion of the placebos with aspirin. E.All of the abo ove are not true 22.Which of the following is NOT part of the endomembrane system? A.Golgi complex. B.Microtubule C.RER D.Smooth endoplasmic reticulum.E.Lysosome 23.The cell membrane consists mainly of A.water and carbondioxide B.cellulose and pectin C.phospholipids and proteins D.actin and myosin E.none ofabove
B.requires ATP chemical energy C.can transport solute from a region of low concentration to a region of high concentration D.all of the above are true. E.none of the above 17.Human red blood cells are the ideal materials to study the cell membrane structures because A. Red blood cells can be easily identified by their color B. Red blood cells are available in large number C. Red blood cells have no nucleus and organelles D. Both B and C E. A+B 18. The muscle contraction requires the action of which molecular motor? A. Kinesin B. Myosin. C. Dynein D. Tubulin E. actin 19. Which of the following about apoptosis is not true? A. Is a sort of cellular self-destruction that can take place in normal tissues. B. Is accompanied by random DNA degradation. C. Is characterized by nuclear fragmentation and cellular breakdown into vesicles. D. Differs from necrosis because necrosis occurs when cell is injured. E. all of above 20. Necrosis A. May be mediated by FAS signal pathway. B. Characterized by DNA degraded into about 200bp fragment. C. Is a genetically controlled process. D. Occurs when cell is injured. E. None of the above 21. In an experiment to test their new drug on humans, two scientists planned to give volunteers one of two drugs: Drug A — experimental drug Drug B — placebo (sugar pill) Which of these would MOST effectively reduce the effect of the bias of the scientists who developed the experimental drug? A. Introduce a third drug into the experiment. B. Decrease the number of experimenters from two to one. C. Have a third researcher label and distribute the samples. D. Replace a portion of the placebos with aspirin. E. All of the above are not true 22. Which of the following is NOT part of the endomembrane system? A.Golgi complex. B.Microtubule C.RER D. Smooth endoplasmic reticulum. E. Lysosome 23. The cell membrane consists mainly of A.water and carbondioxide B. cellulose and pectin C. phospholipids and proteins D. actin and myosin E. none of above
24.The cell cycle's two main stages are called Aanaphase and telophase B.mitosis and interphase C.metaphase and prophase D.cytokinesis and anaphase E.None of the above 25.Meiosis is different from mitosis because meiosis produces A.consistent genetic makeup of all gametes. B.larger daughter cells. C.two gametes for every original parent cell. D.cells with halfthe number of chromosomes E.fast speed of cell division 26.A 56-year-old man who drinks a six pack of beer a day,with higher alcoholic intake on weekends,holidays and"special days,"presents to the internal medicine clinic.He has an abnormal plasma lipoprotein profile.It is known that erythrocyte fluidity is altered in liver disease.Which one of the following would inerease membrane cytes of this patients liver A Restriction of rotational movement of proteins and lipids in the membrane B.Transbilayer movement of phospholipids in the plasma membrane C.Increased cholesterol/phospholipids ratio in the plasma membrane D.Binding of integral membrane proteins with E.Bindingofan anboyto-acee 27.The asymmetry of the cell membrane is established primarily by which one of the following? A.Membrane synthesis in the endoplasmic reticulum B.Membrane modification in the Golgi apparatus C.Presence of carbohydrates on the cytoplasmie surface D.The distribution of cholestero E.Flipping proteins between the leaflets of the lipid bilayer("fip-flop") 28.A44-year-old African American woman calls 911.When the MedAct unit arrives they find a patient with acute obrath an when A pysicl exinon reve pulse 15omma 60-100). ate 42(no mal15-20) s of acce ssory muscle use hing up mu decreased breath sounds with wheezing on inspiration and expiration.The patient has taken her prescribed medications with no relief of symptoms prior to her 911 call.Her current medication is albuterol,a moderately selective B2-receptor agonist.Which one of the following is true regarding those receptors? A.They possess a single hydrophobic transmembrane segment in the form of an a-helix B.They c an activate rionchannels C.They possesan ligand- binding domain D.They posses intrinsic enzyme activity E.They are arranged so that both the amino-and the carboxy-terminals are located intracellularly
24．The cell cycle's two main stages are called A. anaphase and telophase B. mitosis and interphase C. metaphase and prophase D. cytokinesis and anaphase E. None of the above 25. Meiosis is different from mitosis because meiosis produces A. consistent genetic makeup of all gametes. B. larger daughter cells. C. two gametes for every original parent cell. D. cells with half the number of chromosomes. E. fast speed of cell division 26. A 56-year-old man who drinks a six pack of beer a day , with higher alcoholic intake on weekends , holidays , and “special days ,” presents to the internal medicine clinic. He has an abnormal plasma lipoprotein profile. It is known that erythrocyte fluidity is altered in liver disease . Which one of the following would increase membrane fluidity in the hepatocytes of this patient’s liver ? A.Restriction of rotational movement of proteins and lipids in the membrane B. Transbilayer movement of phospholipids in the plasma membrane C .Increased cholesterol/phospholipids ratio in the plasma membrane D. Binding of integral membrane proteins with cytoskeletal elements E. Binding of an antibody to a cell-surface receptor 27. The asymmetry of the cell membrane is established primarily by which one of the following? A. Membrane synthesis in the endoplasmic reticulum B. Membrane modification in the Golgi apparatus C. Presence of carbohydrates on the cytoplasmic surface D. The distribution of cholesterol E. Flipping proteins between the leaflets of the lipid bilayer (“flip-flop”) 28. A 44-year-old African American woman calls 911. When the MedAct unit arrives they find a patient with acute shortness of breath and audible wheezing. A physical examination reveals pulse 115(normal 60-100)， respiratory rate 42 (normal 15-20) with signs of accessory muscle use. She is coughing up mucus. Auscultation reveals decreased breath sounds with wheezing on inspiration and expiration. The patient has taken her prescribed medications with no relief of symptoms prior to her 911 call. Her current medication is albuterol, a moderately selective β2-receptor agonist. Which one of the following is true regarding those receptors? A. They possess a single hydrophobic transmembrane segment in the form of an α-helix B. They can activate plasma membrane-bound enzymes or ion channels C. They posses an intracellular ligand-binding domain D. They posses intrinsic enzyme activity E. They are arranged so that both the amino- and the carboxy-terminals are located intracellularly
29.Which one of the following is the function of the large subunit of the ribosme? A.Bind messenger RNA(mRNA) Bind transfer RNA(tRNA) C Catalyze peptide bond formation D.Initiate protein synthesis E.Link adjacent ribosomes in a polyribosome 30.The stability and arrangement of actin filaments as well as their properties and functions depend on which one of the following? A. The structure of the actin filaments B.Microtubules C.Intermediate filament protein E M uch as kinesin 31.A 14-vear-old adolescent is diagnosed with epidermolysis bullosa simplex (EBS).His skin blisters easily with rubbing or scratching.Blisters occur primarily on his hands and feet and heal without leaving scars.Mutations in the KRT5 and KRT14 genes are identified by genetic analysis.Those genes code for the proteins keratin 5 and keratin 14,respectively.What is the Generate movement B. Provide mechanical stability C.Carry out nucleation of microtubule D.Stabilize microtubules against disassembly E.Transport organelles within the cell 32.A newborn boy is diagnosed with Apert syndrome.He has craniosynostosis,hypoplasia of the middle part of his face with retru sion of the eyesand syndactyly that inudes fusion of the skin of the fingers with moderate fusion of thebones of those digits There is join mobility past the first joint.Which one of the following is most likely decreased in cells in the interdigital region of the developing hand of this newborn child A Random DNA degradation B.Inflammation C.Cell swelling D bel-2 E DNA degradation by endonucleases 33.A15-month-old girl is referred for ophthalmologic and neurologic follow up by her pediatrician.The child has shown a failure to thrive,is microcephalic exhibits myoclonic jerks,delayed psychomotor development.visual disturbance,and seizures.Analysis of fibroblasts from the skin by electron microscopy confirms the presence of fingerprint inclusion bodies.Elevated levels of dolichol are found in the urine.Normally.dolichol is associated with which cellular process? Sulfation in the trans compartment of the Golgi B.O-linked glycosylation in the medial compartment of the Golg C.O-linked glvcosvlation in the cis compartment of the Golgi D.N-linked glycosylation in the endoplasmic reticulum (ER) E.Sorting of proteins to the lysosome form the trans-Golgi network(TGN) 34. Inhibition of actin assembly by cytochalasins would interfere primarily with which one of the following? A. Separation of chromosomes in anaphase of the cell cycle B.Vesicular transport between the Golgi apparatus and cell membrane
29. Which one of the following is the function of the large subunit of the ribosme? A. Bind messenger RNA(mRNA) B. Bind transfer RNA(tRNA) C. Catalyze peptide bond formation D. Initiate protein synthesis E. Link adjacent ribosomes in a polyribosome 30. The stability and arrangement of actin filaments as well as their properties and functions depend on which one of the following ? A. The structure of the actin filaments B. Microtubules C. Intermediate filament protein D. Actin-binding proteins E. Motor molecules , such as kinesin 31. A 14-year-old adolescent is diagnosed with epidermolysis bullosa simplex (EBS). His skin blisters easily with rubbing or scratching. Blisters occur primarily on his hands and feet and heal without leaving scars. Mutations in the KRT5 and KRT14 genes are identified by genetic analysis. Those genes code for the proteins keratin 5 and keratin 14, respectively. What is the primary function of those proteins ? A. Generate movement B. Provide mechanical stability C. Carry out nucleation of microtubules D. Stabilize microtubules against disassembly E. Transport organelles within the cell 32. A newborn boy is diagnosed with Apert syndrome . He has craniosynostosis , hypoplasia of the middle part of his face with retrusion of the eyes , and syndactyly that includes fusion of the skin , connective tissue , and muscle of the first , middle ,and ring fingers with moderate fusion of the bones of those digits . There is very limitied joint mobility past the first joint . Which one of the following is most likely decreased in cells in the interdigital region of the developing hand of this newborn child ? A. Random DNA degradation B. Inflammation C. Cell swelling D. bcl-2 E DNA degradation by endonucleases 33. A 15-month-old girl is referred for ophthalmologic and neurologic follow up by her pediatrician. The child has shown a failure to thrive, is microcephalic exhibits myoclonic jerks, delayed psychomotor development, visual disturbance, and seizures. Analysis of fibroblasts from the skin by electron microscopy confirms the presence of fingerprint inclusion bodies. Elevated levels of dolichol are found in the urine. Normally, dolichol is associated with which cellular process ? A. Sulfation in the trans compartment of the Golgi B. O-linked glycosylation in the medial compartment of the Golgi C. O-linked glycosylation in the cis compartment of the Golgi D. N-linked glycosylation in the endoplasmic reticulum (ER) E. Sorting of proteins to the lysosome form the trans-Golgi network (TGN) 34. Inhibition of actin assembly by cytochalasins would interfere primarily with which one of the following ? A. Separation of chromosomes in anaphase of the cell cycle B. Vesicular transport between the Golgi apparatus and cell membrane