GS MMUNO JANEWAY BIOLOGY KENNETH MURPHY
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Preface Janeway's Immunobiology is intended for under- immunodeficiencies or by failures of immunological graduate and graduate courses in as mechanisms.Chapter 16 describes how the immune lasonmediadentsinOhegbootc9ase eonescanemanpntedtnteontstacomb This chapter includes a complete update of the sistent viewnoin evious oditions ar ed th oughout the book as the relevant topics are encountered. illustrates th loss of any component o from the infection.The companion book.Case ons of Allan Mowat.who ext an dditional,integrated and updated Chapter 12.I welcome Casey Weaver's opics(d nbol nco apters 13 appendices on cytokines and chemokines.I thank Barry Kay for hi suggestions in revising Chapter 14. has made important and rapid developments have work on the previous editions. been extensively revised. The skills give the bool its consistent style and ensure defenses the orderly ctically sound p entation are treated in Chapter 2.The complement system is authors clumsy sketches into the informative yet to the editin pter 3 presented as they are encountered,and not confin in communicating information about this book to a single chapter Signaling pathwaysof he Toll aro und the world Patienc e and support. dlike to thankall those people on the revision plan for this edition.I would also like 12)has be antigen.Mucosal immunology (Chapter to tha the many instructors and students who have microhiota and the the of specialized dendritic cells and regulatory Tcells in suggestionsjustice in this edition.Everyeffort has been a greatly appreciate 13-16 the you let me know. discussed earlier with our latest understanding of the causes of disease,whether by inherited or acquired Kenneth Murphy
Preface Janeway's Immunobiology is intended for undergraduate and graduate courses in immunology, as well as for medical students. The book can be used as an introduction to immunology but its scope is sufficiently comprehensive and deep to be useful for more advanced students and working immunologists. Immunobiology presents immunology from the consistent viewpoint of the host's interaction with an environment full of microbes and pathogens, and illustrates that the loss of any component of this system increases host susceptibility to some particular infection. The companion book, Case Studies in Immunology, provides an additional, integrated discussion of clinical topics (diseases covered in Case Studies are indicated by a symbol in the margin of Immunobiology). This eighth edition retains the overall organization of the previous edition, and chapters in which the field has made important and rapid developments have been extensively revised. The discussion of innate immunity has been substantially expanded and its mechanisms are now treated in two separate chapters, presented in the order in which a pathogen would encounter innate defenses as it attempts to establish an infection. The immediate and soluble defenses are treated in Chapter 2. The complement system is introduced in the context of innate immunity, with the lectin pathway presented before the classical pathway of activation. The induced defenses of innate immunity-including a completely updated treatment of innate sensing-follows in Chapter 3, where various innate cell subsets and their receptors are also described. Signaling pathways are now presented as they are encountered, and not confined to a single chapter. Signaling pathways of the Toll-like receptors and other innate sensors are described in Chapter 3, while antigen receptor signaling pathways and cytokine and apoptotic pathways are retained in Chapter 7. Chapter 10 has been revised to place more emphasis on the trafficking of B cells in peripheral lymphoid organs and the locations at which they encounter antigen. Mucosal immunology (Chapter 12) has been expanded to include more discussion of responses to the commensal microbiota and the role of specialized dendritic cells and regulatory T cells in maintaining tolerance to food antigens and commensal bacteria. The last four chapters-the clinical chapters (Chapters 13-16)-reinforce the basic concepts discussed earlier with our latest understanding of the causes of disease, whether by inherited or acquired I immunodeficiencies or by failures of immunological mechanisms. Chapter 16 describes how the immune response can be manipulated in attempts to combat infectious diseases, transplant rejection, and cancer. This chapter includes a complete update of the immunotherapeutics and vaccine sections. Aspects of evolution, which were confined to the last chapter of previous editions, are now discussed throughout the book as the relevant topics are encountered. The eighth edition has benefited again from the contributions of Allan Mowat, who extensively revised and updated Chapter 12. I welcome Casey Weaver's new contributions to Chapters 13 and 15, and Robert Schreiber's and Joost Oppenheim's revisions to the appendices on cytokines and chemokines. I thank Barry Kay for his suggestions in revising Chapter 14. Most importantly, I acknowledge Charles A. Janeway Jr., Paul Travers, and Mark Walport for their pioneering work on the previous editions. The editors, illustrators, and publishers have contributed in many ways. Eleanor Lawrence's editorial skills give the book its consistent style and ensure the orderly and didactically sound presentation of concepts. Matt McClements has transformed the author's clumsy sketches into the informative yet artistic diagrams that define Janeway's text. Janete Scobie, Bruce Goatly, Sally Huish, Georgina Lucas, and Ioana Moldovan have brought skill and dedication to the editing, proofreading, and typesetting of this edition. Monica Toledo and Michael Morales were key in updating and generating new animations. I thank Adam Sendroff and Lucy Brodie, who are instrumental in communicating information about this book to immunologists around the world, and most of all I thank the publisher Denise Schanck for her incredible patience and support. I would like to thank all those people who read parts or all of the chapters of the seventh edition and advised on the revision plan for this edition. I would also like to thank the many instructors and students who have taken the time to write to me with their suggestions on how to improve the book. I hope I have done those suggestions justice in this edition. Every effort has been made to write a book that is error-free. Nonetheless, you may find them, and I would greatly appreciate it if you let me know. Kenneth Murphy E
Instructor and Student Resources Websites Accessible from www.garlandscience.com,these Student Resources:The following resources are provide and each for Janeway's com/stu of the On the websites,the resources may be browsed by Animations and Videos The 40 animations and videos dynamically illustrate of the more diffcult to throughout the text indicate the relevant media. av ctor Site ach Flashc oter contains a set of flashcards.built into the The Art of Janeway's Immuno website,that allow students to review key terms from The images the boo are the text have been optimized for display on a computer The complete glossary from the book is available on or bykeywo be searched and browsed as a Animations and Videos are created for instructors who wish to use the t presentatio s on Window 6 uters or Keynote uo ode to your PC e movi prev ew page from the ovt ha presentations.These will be useful for instructors th would d tart in creating lecture cousell of Ca or example the content of these presentaon the classroom. PowerPoint and Word are registered trademarks of Microsof Corporation in the United Statesand/orother Keynote is a registered trademark ofApple Inc
Instructor and Student Resources Websites Accessible from www.garlandscience.com, these websites provide learning and teaching tools created for Janeway's Immunobiology, Eighth Edition. Below is an overview of the resources available for this book. On the websites, the resources may be browsed by individual chapters and there is a search engine. You can also access the resources available for other Garland Science titles. Instructor Resources: The following resources are available on the Instructor Site: The Art of Janeway's Immunobiology, Eighth Edition The images from the book are available in two convenient formats: PowerPoint® and JPEG. They have been optimized for display on a computer. Figures are searchable by figure number, figure name, or by keywords used in the figure legend from the book. Animations and Videos The 40 animations and videos that are available to students are also available on the Instructor's Site in two formats. The WMV-formatted movies are created for instructors who wish to use the movies in PowerPoint presentations on Windows® computers; the QuickTime-formatted movies are for use in PowerPoint for Apple computers or Keynote® presentations. The movies can easily be downloaded to your PC using the 'download' button on the movie preview page. Figure Integrated Lecture Outlines The section headings, concept headings, and figures from the text have been integrated into PowerPoint presentations. These will be useful for instructors who would like a head start in creating lectures for their course. Like all of Garland Science's PowerPoint presentations, the lecture outlines can be customized. For example, the content of these presentations can be combined with videos on the website to create unique lectures that facilitate interactive learning in the classroom. Student Resources: The following resources are available on the Student Site at www.garlandscience. com/ students/immunobiology: Animations and Videos The 40 animations and videos dynamically illustrate important concepts from the book, and make many of the more difficult topics accessible. Icons located throughout the text indicate the relevant media. Flashcards Each chapter contains a set of flashcards, built into the website, that allow students to review key terms from the text. Glossary The complete glossary from the book is available on the website and can be searched and browsed as a whole or sorted by chapter. PowerPoint and Word are registered trademarks of Microsoft Corporation in the United States and/or other countries. Keynote is a registered trademark of Apple Inc
Acknowledgments Research,ondon;Steve Reiner,University of Pennsylvania with invaluable advice in developing thisnewedtion. for Medical Research.London. kinger, nstitute Chapter 1:Hans Acha-Orbea,Universite de Lausanne;Eliza- Chapter 9:Katherine Calame,Columbia University;Michael Medicine Lewis Lani .of Francisco versity of Medic al Sch Cambridge. ne The Campus de luminv. ripps Research Michae cine.switerland. Robyn Stanfield.The Scripps Res arch Institute:lan Wilson Chapter 11:Chuck Elson.University of Alabama:Michael The Scripps Research Institute. ld.Ba Case Western Reserve:Thomas MacDon sity of Milan;Michael Russell,University at Buffalo. icine:Barry Sleckmar de Rech pitalier Necker Ir Gena,Ha oI Me cine; 密 Chapter 14:Anne Davidson,Albert Einstein College of RIKEN ；Larry Samel National Human Genome Research Institute.NIH:Art Weiss Pennsylvania School of Medicine:Rikard Holmdahl.Lund University of California,San Francisco. Cancr to Univ RichardHardy,Fox Chase Cancer Center Kris Hogquist.Uni sota;John】 National Institute for Medical Research,London. Chapter Litm. University of South Florida;Martin Flajnik University of Oxford:Bill Heath.University of Melbo Victoria;Anne O'Garra,The National Institute for Medical versity of Alabama at Birmingham
Acknowledgments We would like to thank the following experts who read parts or the whole of the seventh edition chapters and provided us with invaluable advice in developing this new edition. Chapter 1: Hans Acha-Orbea, Universite de Lausanne; Elizabeth Godrick, Boston University; Michael Gold, University of British Columbia; Derek McKay, University of Calgary. Chapter 2: Shizuo Akira, Osaka University; Lewis Lanier, University of California, San Francisco; Gabriel Nunez, University of Michigan Medical School; Philip Rosenstiel, University of Kiel, Germany; Hung Bing Shu, Wuhan University, China; Caetano Reis e Sousa, Cancer Research UK; Tada Taniguchi, University of Tokyo; Andrea Tenner, University of California, Irvine; Eric Vivier, Universite de Ia Mediterranee Campus de Luminy. Chapter 3: Bernard Malissen, Centre d' Immunologie Marseille-Luminy; Ellis Reinherz, Harvard Medical School; Robyn Stanfield, The Scripps Research Institute; Ian Wilson, The Scripps Research Institute. Chapter 4: Michael Lieber, University of Southern California; Michael Neuberger, University of Cambridge; David Schatz, Yale University School of Medicine; Barry Sleckman, Washington University School of Medicine, St. Louis; Philip Tucker, University of Texas, Austin. Chapter 5: Siamak Bahram, Centre de Recherche d'Immunologie et d'Hematologie; Peter Cresswell, Yale University School of Medicine; Mitchell Kronenberg, La Jolla Institute for Allergy & Immunology; Philippa Marrack, Howard Hughes Medical Institute; Hans-Georg Rammensee, University ofTubingen, Germany. Chapter 6: Oreste Acuto, University of Oxford; Leslie Berg, University of Massachusetts Medical Center; Doreen Cantrell, University of Dundee, UK; Andy Chan, Genentech, Inc.; Vigo Heissmeyer, Helmholtz Center Munich; Steve Jameson, University of Minnesota; Gabriel Nunez, University of Michigan Medical School; Takashi Saito, RIKEN; Larry Samelson, National Cancer Institute, NIH; Pamela Schwartzberg, National Human Genome Research Institute, NIH; Art Weiss, University of California, San Francisco. Chapter 7: Michael Cancro, University of Pennsylvania School of Medicine; Robert Carter, University of Alabama; Richard Hardy, Fox Chase Cancer Center; Kris Hogquist, University of Minnesota; John Monroe, Genentech, Inc.; Nancy Ruddle, Yale University School of Medicine; Marc Veldhoen, National Institute for Medical Research, London. Chapter 8: Michael Bevan, University of Washington; Frank Carbone, University of Melbourne, Victoria; Gillian Griffiths, University of Oxford; Bill Heath, University of Melbourne, Victoria; Anne O'Garra, The National Institute for Medical Research, London; Steve Reiner, University of Pennsylvania School of Medicine; Brigitta Stockinger, National Institute for Medical Research, London. Chapter 9: Katherine Calame, Columbia University; Michael Cancro, University of Pennsylvania School of Medicine; Robert H. Carter, The University of Alabama, Birmingham; Jason Cyster, University of California, San Francisco; John Kearney, The University of Alabama, Birmingham; Garnett Kelsoe, Duke University; Michael Neuberger, University of Cambridge. Chapter 10: Michael Bevan, University ofWashington; Marc K. Jenkins, University of Minnesota; Robert Modlin, University of California, Los Angeles; Michael Oldstone, The Scripps Research Institute; Michael Russell, University at Buffalo; Federica Sallusto, Institute for Research in Biomedicine, Switzerland. Chapter 11: Chuck Elson, University of Alabama; Michael Lamm, Case Western Reserve University; Thomas MacDonald, Barts and T he London School of Medicine and Dentistry; Kevin Maloy, University of Oxford; Maria Rescigno, University of Milan; Michael Russell, University at Buffalo. Chapter 12: Jean-Laurent Cassanova, Groupe Hospitalier Necker-Enfants-Malades, Paris; Mary Collins, University College London; Alain Fischer, Groupe Hospitalier NeckerEnfants-Malades, Paris; Raif Geha, Harvard Medical School; Paul Klenerman, Oxford University; Luigi Notarangelo, Harvard Medical School; Sarah Rowland-Jones, Oxford University; Adrian Thrasher, London Institute of Child Health. Chapter 13: Cezmi A. Akdis, Swiss Institute of Allergy and Asthma Research; Barry Kay, National Heart and Lung Institute; Raif Geha, Harvard Medical School; Gabriel Nunez, University of Michigan Medical School; Albert Sheffer, Harvard Medical School. Chapter 14: Anne Davidson, Albert Einstein College of Medicine; Robert Fairchild, Cleveland Clinic; Fadi Lakkis, University of Pittsburgh; Wayne Hancock, University of Pennsylvania School of Medicine; Rikard Holmdahl, Lund University; Laurence A. Turka, University of Pennsylvania School of Medicine. Chapter 15: Benny Chain, University College London; James Crowe, Vanderbilt University; Glen Dranoff, Dana Farber Cancer Institute; Giuseppe Pantaleo, Universite de Lausanne; Richard 0. Williams, Imperial College of London. Chapter 16: Jim Kaufman, University of Cambridge; Gary W. Litman, University of South Florida; Martin Flajnik, University of Maryland, Baltimore; Robert Schreiber, Washington University School of Medicine, St. Louis; Casey Weaver, University of Alabama at Birmingham