The sulfa drugs were the first widely used growth factor analogs to specifically inhibit the growth of bacteria.磺胺类药物 H2N SO2NH2 H2N COOH (a)Sulfanilamide (b)p-Aminobenzoic acid H CH2-N- O= COOH HN-C-H H2N CH2 CH2 COOH (c)Folic acid 2012 Pearson Education.Inc
The sulfa drugs were the first widely used growth factor analogs to specifically inhibit the growth of bacteria.磺胺类药物
Sulfanilamide is an analog of p-aminobenzoic acid,which is a part of the vitamin folic acid.Sulfanilamide acts by blocking the synthesis of folic acid,a nucleic acid precursor..磺胺是对氨基苯甲酸的类似物，可阻断叶酸的合成. H2N SO2NH2 H2N COOH (a)Sulfanilamide (b)p-Aminobenzoic acid cHs片 COOH HN-C-H CH2 CH2 COOH (c)Folic acid 2012 Pearson Education,Ing
Sulfanilamide is an analog of p-aminobenzoic acid, which is a part of the vitamin folic acid. Sulfanilamide acts by blocking the synthesis of folic acid, a nucleic acid precursor.磺胺是对氨基苯甲酸的类似物, 可阻断叶酸的合成
Sulfanilamide is active in bacteria but not in higher animals,why? Bacteria synthesize their own folic acid,whereas higher animals obtain folic acid from their diet.细菌自己合成叶酸，而高等动物从饮 食中获取叶酸. H2N SO2NH2 H2N COOH (a)Sulfanilamide (b)p-Aminobenzoic acid H CH2 N- o=0- COOH HN-C-H CH2 CH2 COOH (c)Folic acid 2012 Pearson Education.ine
Sulfanilamide is active in bacteria but not in higher animals,why? Bacteria synthesize their own folic acid, whereas higher animals obtain folic acid from their diet.细菌自己合成叶酸, 而高等动物从饮 食中获取叶酸
上降充通大学 Shanghai Jiao Tong University 6.6.2 Other Growth Factor Analogs Isoniazid,a nicotinamide (vitamin)analog,is effective only against Mycobacterium tuberculosis, 烟肼，烟碱的类似物，仅作用于结核分支杆菌 Mechanism:interfere with the synthesis of mycobacterial-specific mycolic acid影响分支杆菌 特异性的分支菌酸合成， Shanghai Jiao Tong University
Shanghai Jiao Tong University 6.6.2 Other Growth Factor Analogs Isoniazid, a nicotinamide (vitamin) analog, is effective only against Mycobacterium tuberculosis,异 烟肼, 烟碱的类似物,仅作用于结核分支杆菌. Mechanism: interfere with the synthesis of mycobacterial-specific mycolic acid 影响分支杆菌 特异性的分支菌酸合成