上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Lecture 8-2 Metabolic Regulation (Regulation of gene expression) CHAPTER 8 in BROCK BIOLOGY OF MICROORGANISMS Chen Feng School of Life Science and Technology Shanghai Jiao Tong University Email:cf2001@situ.edu.cn http://micro.sjtu.edu.cn
1896 1920 1987 2006 Lecture 8-2 Metabolic Regulation (Regulation of gene expression) Chen Feng School of Life Science and Technology Shanghai Jiao Tong University Email: cf2001@sjtu.edu.cn http://micro.sjtu.edu.cn CHAPTER 8 in BROCK BIOLOGY OF MICROORGANISMS
上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 IlI.DNA-Binding Proteins and Regulation of Transcription by Negative and Positive Control (Transcriptional level regulation) DNA结合蛋白与转录水平的调控
1896 1920 1987 2006 III. DNA-Binding Proteins and Regulation of Transcription by Negative and Positive Control (Transcriptional level regulation) DNA结合蛋白与转录水平的调控
上浒充通大淫 SHANGHAI JIAO TONG UNIVERSITY 8.5 Negative control of transcription: Repression and Induction转录的负调控 Repression阻遏 End product of a pathway inhibits transcription of genes for enzymes in its synthesis Induction诱导 Gene of an enzyme will be transcribed only when its substrate is present Chen Feng,Shanghai Jiao Tong University
Chen Feng, Shanghai Jiao Tong University 8.5 Negative control of transcription: Repression and Induction转录的负调控 Repression阻遏 • End product of a pathway inhibits transcription of genes for enzymes in its synthesis Induction诱导 • Gene of an enzyme will be transcribed only when its substrate is present
上游充通大￥ SHANGHAI JIAO TONG UNIVERSITY Example of Repression of Transcription阻遏例子 Repression Enzymes involved in formation of arginine Cell number. Total are synthesized only protein when arginine is absent from the medium Arginine added External arginine represses the synthesis Arginine biosynthesis of these enzymes. enzymes Time 2012 Pearson Education,inc
Chen Feng, Shanghai Jiao Tong University Example of Repression of Transcription阻遏例子 Enzymes involved in formation of arginine are synthesized only when arginine is absent from the medium External arginine represses the synthesis of these enzymes
上降充通大粤 SHANGHAI JIAO TONG UNIVERSITY xample of Induction of Transcription诱导例子 Induction Total protein If lactose is absent from the medium the enzyme is not synthesized,but Cell number synthesis begins almost immediately after lactose B-Galacto- is added. sidase Lactose added Time 2012 Pearson Education,Inc
Chen Feng, Shanghai Jiao Tong University Example of Induction of Transcription诱导例子 If lactose is absent from the medium the enzyme is not synthesized, but synthesis begins almost immediately after lactose is added