上充通大学 SHANGHAI JLAO TONG UNIVERSITY 1896 1920 1987 2006 Virus:Growth,quantification,replication and diversity Lecture 9-3 Essentials of Virology NGHAIJIAO TON NG Chen Feng School of Life Science and Biotechnology. Shanghai Jiao Tong University Email:cf2001@sjtu.edu.cn http://micro.sjtu.edu.cn
Lecture 9-3 Essentials of Virology Virus: Growth, quantification, replication and diversity Chen Feng School of Life Science and Biotechnology, Shanghai Jiao Tong University Email: cf2001@sjtu.edu.cn http://micro.sjtu.edu.cn
上泽充通大￥ SHANGHAI JLAO TONG UNIVERSITY 1896 1920 1987 2006 强 ■■品是是 9.11 Overview of Animal Viruses ANGHAIJIAO TONG 1日9G ■■盒
9.11 Overview of Animal Viruses
9.11.1 Differences between prokaryotes and eukaryotes that affect virus multiplication 1.Entrance into the cell:Absence or presence of cell wall For many bacteriophages only the genome and perhaps one or two proteins penetrate into the cytoplasm itself. For animal viruses,the entire virion or at least the nucleocapsid enters the cytoplasm by endocytosis and then must be uncoated. 2.Site for replication:Cellular compartmentation No compartmentation in prokaryotes Compartmentation in eukaryotes(DNA replication and transcription occur in the nucleus,whereas translation occurs in the cytoplasm) Chen Feng,Shanghai Jiao Tong University
Chen Feng, Shanghai Jiao Tong University 9.11.1 Differences between prokaryotes and eukaryotes that affect virus multiplication 1. Entrance into the cell: Absence or presence of cell wall • For many bacteriophages only the genome and perhaps one or two proteins penetrate into the cytoplasm itself. • For animal viruses, the entire virion or at least the nucleocapsid enters the cytoplasm by endocytosis and then must be uncoated. 2. Site for replication: Cellular compartmentation • No compartmentation in prokaryotes • Compartmentation in eukaryotes (DNA replication and transcription occur in the nucleus, whereas translation occurs in the cytoplasm)
9.11.1 Differences between prokaryotes and eukaryotes that affect virus multiplication 3.mRNA synthesis and protein translation Polycistronic for bacteria Monocistronic for eukaryotes Chen Feng,Shanghai Jiao Tong University
Chen Feng, Shanghai Jiao Tong University 3. mRNA synthesis and protein translation • Polycistronic for bacteria • Monocistronic for eukaryotes 9.11.1 Differences between prokaryotes and eukaryotes that affect virus multiplication
9.11.2 Classification of animal viruses Nonenveloped Enveloped partially 每 dsDNA ssDNA Parvovirus Hepadnavirus dsDNA Papovavirus dsDNA dsDNA Poxvirus Adenovirus dsDNA dsDNA Herpesvirus Iridovirus 100nm (a)DNA viruses 2012 Pearson Education,ing. Parvovirus细小病毒papovavirus乳关多瘤空泡病毒adenovirus.腺病毒iridovirus!虹彩病 毒hepadnavirust嗜肝DNA病毒 poxvirus痘病毒herpesvirus疱疹病毒
9.11.2 Classification of animal viruses Parvovirus细小病毒 papovavirus乳关多瘤空泡病毒 adenovirus腺病毒 iridovirus虹彩病 毒 hepadnavirus嗜肝DNA病毒 poxvirus痘病毒 herpesvirus疱疹病毒