上海交通大学：《微生物学 Microbiology》课程教学资源（双语课件）Lecture 6.2 Microbial Growth Control in vitro and in vivo（ANTIMICROBIAL AGENTS USED IN VIVO 体内使用的抗微生物制剂、ANTIMICROBIAL DRUG RESISTANCE AND DRUG DISCOVERY 抗药性与新药研制）

Antibiotic Subelassification Example Representative structure classification X. Quinolone 4-Quinolone Nalidixic acid C2H5 compounds Fluoro-4-quinolones Ciprofloxacin Fosfomycin H3C、 喹诺酮类 COOH 0 Nalidixic acid XI.Oxazolidinone Cyclic lactone 2-Oxazolidinone 2-Oxazolidinone 噁唑类 gy of Microorganisms 11/e C

喹诺酮类 噁唑类

Mode of action of antibacterial agents Cell wall synthesis DNA gyrase DNA-directed RNA polymerase RNA elongation Cycloserine Quinolones Nalidixic acid Rifampin Vancomycin Ciprofloxacin Actinomycin Streptovaricins Bacitracin Novobiocin Penicillins Cephalosporins Protein synthesis Monobactams (50S inhibitors) Carbapenems Erythromycin(macrolides) DNA Chloramphenicol Clindamycin Folic acid metabolism Lincomycin Trimethoprim THF mRNA Sulfonamides、 米 Protein synthesis Ribosomes (30S inhibitors) 50 50 50 Tetracyclines 30 30 30 Spectinomycin Streptomycin Gentamicin Cytoplasmic membrane Kanamycin structure and function Amikacin Polymyxins Lipid Nitrofurans Daptomycin biosynthesis Protein synthesis Platensimycin (tRNA】 PABA Cytoplasmic Cell wall Mupirocin membrane Puromycin 2012 Pearson Education,Inc. FL ASH 中文名

Mode of action of antibacterial agents FLASH 中文名

Eukaryotes Bacteria Obligately parasitic Bacteria Viruses RNA DNA Fungi Mycobacteria Gram-negative Gram-positive Chlamydia Rickettsia Iviruses viruses Bacteria Bacteria Tobramycin Penicillins Nonnucleoside Azoles reverse transcriptase Allylamines Sulfonamides inhibitors Cycloheximide J Cephalosporins Polyenes Streptomycin Quinolones Protease inhibitors Fusion inhibitors Polyoxins Nucleic acid Tetracycline L INucleoside analogs analogs Interferon Echinocandins Isoniazid Polymyxins Vancomycin Daptomycin Platensimycin 2012 Pearson Education,Inc. Characteristic spectrum of antibacterial action of different agents 每种抗生素都有其特定的抗菌谱

Characteristic spectrum of antibacterial action of different agents 每种抗生素都有其特定的抗菌谱

充通大学 i Shanghai Jiao Tong University 漏 6.6 Synthetic Antimicrobial Drugs HANGH 人工合成的抗微生物药物 JIAO TONG

6.6 Synthetic Antimicrobial Drugs 人工合成的抗微生物药物

上泽充至大学 Shanghai Jiao Tong University 6.6.1 Growth Factor Analogs:Sulfa Drugs 磺胺类药物 Growth factor analogs:compounds that are structurally similar to the growth factors, but their structural differences prevent them from duplication the function of the natural G.Domagk growth factor in the cell..生长因子类似物： 与生长因子的结构相似，但不具有生长因 子的功能 Shanghai Jiao Tong University

Shanghai Jiao Tong University 6.6.1 Growth Factor Analogs: Sulfa Drugs 磺胺类药物 Growth factor analogs: compounds that are structurally similar to the growth factors, but their structural differences prevent them from duplication the function of the natural growth factor in the cell.生长因子类似物: 与生长因子的结构相似,但不具有生长因 子的功能. G. Domagk